PMID: 2506605Jan 1, 1989Paper

Neuroleptic-induced emotional defecation: effects of scopolamine and haloperidol

Psychopharmacology
P R SanbergD L Garver

Abstract

Most investigators have found a decrease in emotional defecation in rats given neuroleptics in novel environments, supporting their action as a major tranquilizer. We have found, however, that in rats a profound increase in emotional defecation can result from neuroleptic administration in well habituated environments, such as the homecage. Anticholinergics are known to be effective in treating the side effects associated with neuroleptic administration in humans. Therefore the present study determined the effects of anticholinergic treatment in this animal model. In male rats, defecation was measured for a 1-h test period in their homecage following various doses of the central and peripheral anticholinergics, scopolamine, and n-methylscopolamine, respectively. A decrease in fecal excretions and an attenuation of haloperidol-induced defecation was found following administration of scopolamine. n-Methylscopolamine reduced defecation at all doses. When n-methylscopolamine was combined with haloperidol, both fecal mass and number decreased significantly. Since both anticholinergic agents reduced haloperidol-induced defecation it is suggested that their effectiveness is mediated through peripheral mechanisms.

References

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Citations

Feb 1, 1991·Biological Psychiatry·D F Emerich, P R Sanberg
Oct 2, 1990·European Journal of Pharmacology·H H BerendsenA M Van Delft
Apr 1, 1993·Psychiatry Research·P SachdevF Westbrook
Apr 27, 2000·Neuroscience and Biobehavioral Reviews·P S Sachdev, M Brüne
May 1, 1995·British Journal of Pharmacology·T CrociL Manara
Apr 1, 1992·The Journal of Pharmacy and Pharmacology·T Croci, A Bianchetti
May 1, 1994·The Journal of Pharmacy and Pharmacology·T CrociL Manara
Dec 5, 2009·CNS Drugs·Chi-Un PaeAshwin A Patkar

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