PMID: 38473May 25, 1979

Neuroleptic influence on hyperthermia induced by 5-hydroxytryptophan and p-methoxy-amphetamine in MAOI-pretreated rabbits

B Fjalland


5-Hydroxytryptophan (5-HTP) and p-methoxyamphetamine (p-MA) induce dose-dependent, lethal hyperthermia when applied intravenously to monoamine oxidase inhibitor (MAOI) pretreated rabbits. The time course of hyperthermia and the doses required to induce hyperthermia varies between the two substances. Results with alpha-MT and PCPA suggest that 5-HTP hyperthermia depends on 5-HT formation, release of endogenous 5-HT, and the presence of catecholamines, whereas p-MA-induced hyperthermia most likely is a result of indirect 5-HT release. Some neuroleptics (piflutixol, spiroperidol and methiotepine) are extremely potent inhibitors of the induced hyperthermia, Also the 5-HT receptor blocking agent methergoline antagonizes hyperthermia induced by the two substances in rather low doses. On the other hand cis (Z)-flupenthixol is a very weak antagonist of 5-HTP but a more potent inhibitor of p-MA hyperthermia. It is concluded that both 5-HT and catecholamine (dopamine) receptor blockade is required to antagonize 5-HTP hyperthermia and that antagonism of p-MA induced hyperthermia is primarily a result of influence on the 5-HT system.


Mar 1, 1978·Acta Pharmacologica Et Toxicologica·B Fjalland, V Boeck
Apr 1, 1977·The Journal of Physiology·D BorsookC J Woolf
Mar 9, 1978·Nature·J E LeysenP M Laduron
Oct 1, 1977·Acta Pharmacologica Et Toxicologica·I M NielsenO Svendsen
Apr 1, 1974·The Journal of Pharmacy and Pharmacology·C Gardey-Levassort, P Lechat
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·I M NielsenA V Christensen
May 1, 1974·European Journal of Pharmacology·A L Frankhuijzen, I L Bonta


Nov 26, 1988·Lancet·P M Graham, K F Ilett
Apr 30, 1999·Journal of Psychopharmacology·P K Gillman
Jun 11, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Roni ShilohDan-Andrei Waitman
Jun 1, 1991·DICP : the Annals of Pharmacotherapy·M L LevinsonD K Fuller

Related Concepts

Depression, Chemical
Drug Interactions
RIMA (Reversible Inhibitor of Monoamine Oxidase A)
Antipsychotic Effect

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