PMID: 8590492Nov 1, 1995Paper

Neuroleptic malignant-like syndrome: a complication of acute organophosphate poisoning

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
G OchiT Arai

Abstract

We report a 60-yr-old woman with schizophrenia, who manifested a neuroleptic malignant (NM)-like syndrome after acute organophosphate poisoning (OPP). She attempted suicide by ingesting 40% emulsions of DMTP (S-2,3-dihydro-5-methoxy-2-oxo-1,3,4-thiadizol-3-yl-methyl O,O-dimethyl phosphorodithioate) 100 ml. On admission, she was unconscious and demonstrated convulsions, depressed respiratory movements, miosis and profuse salivation. Plasma cholinesterase concentration (842 IU.L-1) was very low and OPP was diagnosed. She was treated with gastric lavage, atropine and pralidoxime (PAM). By the seventh day after admission, symptoms of OPP disappeared and serum ChE had recovered to a sub-normal level. On the 13th day, she demonstrated coma, high fever (41.0 degrees C) and lead-pipe rigidity. Serum CPK was increased (1631 IU.L-1). Dantrolene sodium iv was administered for three days. Body temperature began to decrease in 24 hr, and her consciousness, muscle rigidity and other neurological symptoms returned to normal by the 16th day after admission. She was discharged from the hospital without sequelae 55 days after admission. We conclude that OPP can predispose to an NM-like syndrome and that dantrolene may be effective in the managem...Continue Reading

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Citations

Mar 20, 2010·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Alison MoffattNick A Buckley
May 5, 2004·Best Practice & Research. Clinical Rheumatology·Sandrine GuisFrédéric Lioté
Dec 14, 1999·Anaesthesia·L Karalliedde
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Haleh TalaieOmid Mehrpour
Jul 1, 1996·Reviews on Environmental Health·C J Gordon
Dec 13, 2005·Reviews on Environmental Health·Chandrabhan Dharmani, Kushik Jaga
Jul 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P HantsonP Mahieu
Oct 9, 2015·Indian Journal of Pediatrics·N Ravishankar
Mar 15, 1997·Annals of the New York Academy of Sciences·C J Gordon, Y Yang

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