PMID: 6111584May 1, 1981Paper

Neuroleptic malignant syndrome-like state following a withdrawal of antiparkinsonian drugs

The Journal of Nervous and Mental Disease
M ToruK Sugano

Abstract

A 63-year-old woman with diagnosis of Parkinson's disease developed an unusual symptom complex which consisted of extrapyramidal symptoms, disturbances of consciousness, diaphoresis, fever, and increased serum creatine phosphokinase following the discontinuation of large doses of combined antiparkinsonian drugs. After the patient's condition did not improve with the first 14 days of treatment consisting of intravenous fluids and antibiotics, a trial administration of L-dopa and carbidopa brought about definite clinical improvement. The symptoms strongly resembled neuroleptic malignant syndrome which is often a serious complication of antipsychotic drugs. The symptoms and the treatment of the present case suggest that dopaminergic hypoactivity in the brain may be an important factor in antiparkinsonian drug withdrawal syndrome and that similar neurochemical mechanisms may exist in neuroleptic malignant syndrome.

Citations

Dec 1, 1987·Journal of Neurology·D T Martin, M Swash
Jan 1, 1993·Journal of Neural Transmission. General Section·J Kornhuber, M Weller
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·J KornhuberP Riederer
Feb 1, 1989·Italian Journal of Neurological Sciences·L Figà-Talamanca, C Gualandi
May 6, 2009·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Eric BrantleyKavita Babu
Jul 10, 2008·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marco SimonettoGilberto Pizzolato
Aug 21, 2008·Neurocritical Care·Edward J NewmanPeter G E Kennedy
Mar 1, 1985·Biological Psychiatry·G L Fricchione
Aug 1, 1987·Biological Psychiatry·G AddonizioS D Roth
Feb 1, 1990·Biological Psychiatry·K Nisijima, T Ishiguro
Jan 1, 1984·Pharmacology & Therapeutics·W G Clark, J M Lipton
Jan 1, 1990·Progress in Neuro-psychopharmacology & Biological Psychiatry·J de LeonI de la Serna
Jul 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·S S GratzG M Simpson
Nov 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·U Müller, D Y von Cramon
Dec 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Amore, N Zazzeri
Apr 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·G SechiG Rosati
Sep 1, 1993·Clinical Neurology and Neurosurgery·P J Poels, F J Gabreëls
Jan 1, 1990·General Pharmacology·M EbadiL C Murrin
Apr 20, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Alexander Meigal, Yurij Lupandin
Nov 14, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·K IwahashiY Ichikawa
Aug 1, 1985·Psychosomatics·P S Mueller
Mar 1, 1984·La Revue du praticien·F HilpertP Auzépy
Jul 1, 1997·Neuroscience and Biobehavioral Reviews·K W LangeP Riederer
May 9, 2003·Parkinsonism & Related Disorders·Takao HashimotoNobuo Yanagisawa
May 9, 2003·Parkinsonism & Related Disorders·Hideki TakuboYoshikuni Mizuno
May 9, 2003·Parkinsonism & Related Disorders·Hideki TakuboHirotaro Narabayashi
May 9, 2003·Parkinsonism & Related Disorders·Toshihide HaradaShigenobu Nakamura
May 9, 2003·Parkinsonism & Related Disorders·Yoshikuni MizunoSadako Kuno
Jul 18, 1985·The New England Journal of Medicine·B H Guzé, L R Baxter
Jan 1, 1987·The Journal of General Psychology·J B Murray
Aug 3, 2006·Journal of Psychiatric Practice·Dilek MemisJack M Gorman
Feb 1, 2005·Southern Medical Journal·Ryan C W HallRichard C W Hall
Apr 1, 1990·Anaesthesia·J N Montgomery, J W Ironside
Jan 1, 1986·Postgraduate Medical Journal·W R Gibb, D N Griffith
Nov 7, 2009·Annals of Indian Academy of Neurology·C J Suresh Chandran
Aug 8, 2014·Clinical Medicine : Journal of the Royal College of Physicians of London·Nirmalan ArulananthamTom Hayton
Apr 1, 1989·Biological Psychiatry·H HermeshJ Eviatar
Sep 1, 1992·The International Journal of Neuroscience·R Sandyk, G L Willis
Jan 1, 1989·The International Journal of Neuroscience·R Sandyk
Aug 9, 2003·Expert Opinion on Drug Safety·Debra K Farver

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here