Neuroleptic malignant syndrome: mechanisms, interactions, and causality

Movement Disorders : Official Journal of the Movement Disorder Society
P Ken Gillman

Abstract

This review focuses on new data from recent publications concerning how compounding interactions between different thermoregulatory pathways influence the development of hyperthermia and/or neuroleptic malignant syndrome (NMS), and the fundamental issue of the presumed causal role of antipsychotic drugs. The formal criteria for substantiating cause-effect relationships in medical science, established by Hill, are applied to NMS and, for comparison, also to malignant hyperthermia and serotonin toxicity. The risk of morbidities related to hyperthermia is reviewed from human and experimental data: temperatures in excess of 39.5°C cause physiological and cellular dysfunction and high mortality. The most temperature-sensitive elements of neural cells are mitochondrial and plasma membranes, in which irreversible changes occur around 40°C. Temperatures of up to 39°C are "normal" in mammals, so, the term hyperthermia should be reserved for temperatures of 39.5°C or greater. The implicitly accepted presumption that NMS is a hypermetabolic and hyperthermic syndrome is questionable and does not explain the extensive morbidity in the majority of cases, where the temperature is less than 39°C. The thermoregulatory effects of dopamine and ac...Continue Reading

References

Sep 1, 1978·The Journal of Physiology·B CoxT F Lee
Jan 1, 1975·British Journal of Anaesthesia·G G Harrison
Jun 1, 1976·Anesthesiology·G A GronertR A Theye
Mar 1, 1992·Italian Journal of Neurological Sciences·U BonuccelliA Muratorio
Jul 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·S S GratzG M Simpson
Jul 20, 1991·Lancet·P I Rosebush, M F Mazurek
Nov 11, 1991·International Journal of Biometeorology·G E Folk, H A Semken
Nov 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P I RosebushM F Mazurek
Oct 1, 1991·The American Journal of Psychiatry·R J Gurrera
Aug 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·A M Kellam
Jul 1, 1990·Biological Psychiatry·P E KeckS L McElroy
Feb 1, 1990·Medicine and Science in Sports and Exercise·R W Hubbard
Jun 1, 1989·Journal of Applied Physiology·A DeschampsS Magder
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·R F Pfeiffer, E L Sucha
Oct 1, 1986·The American Journal of Psychiatry·H G PopeS L McElroy
Jun 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·A M Kellam
Mar 1, 1987·Pharmacology & Toxicology·D NielsenP T Andersen
Sep 1, 1987·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P Patel, G Bristow
Jun 1, 1986·Experimental Eye Research·P R Greene, D L Guyton
Dec 1, 1986·The American Journal of Psychiatry·G AddonizioS D Roth
Nov 15, 1985·JAMA : the Journal of the American Medical Association·J H FriedmanR G Feldman
Nov 15, 1985·JAMA : the Journal of the American Medical Association·R Sangal, R Dimitrijevic
Oct 1, 1973·Current Problems in Pediatrics·M Lewis, D O Lewis
Apr 1, 1972·Journal of Applied Physiology·J M DetryC Wyss
Nov 1, 1969·Journal of Applied Physiology·L B RowellJ A Murray
May 1, 1981·The Journal of Nervous and Mental Disease·M ToruK Sugano
Feb 1, 1982·Neurology·I S LoginR M MacLeod
Jul 3, 1982·Lancet·J G Goekoop, P A Carbaat
Jan 21, 1983·JAMA : the Journal of the American Medical Association·P S MuellerJ Fermaglich
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·C T Davies
Jul 1, 1980·Archives of Neurology·H H MorrisJ A Reinarz
Jan 1, 1995·The Journal of Neuropsychiatry and Clinical Neurosciences·P E KeckS L McElroy
Aug 1, 1995·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·J Harker, P Gibson
Mar 1, 1994·The Journal of Nervous and Mental Disease·V R VelamoorR E Antelo
Jan 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·M OssemannC Laterre
Mar 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·G M Petzinger, S B Bressman
Aug 1, 1997·The American Journal of Psychiatry·P SachdevD Hadzi-Pavlovic
Mar 26, 1998·Biological Psychiatry·P ThomasM Goudemand
May 20, 1998·Journal of the Neurological Sciences·B Yaqub, S Al Deeb
Jun 3, 1998·Intensive Care Medicine·E StevensN Jaspar
Aug 8, 1998·Annals of Internal Medicine·J E DematteI M Ndukwu
Oct 6, 1998·Archives of Internal Medicine·P A Mackowiak

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Citations

Nov 22, 2011·Journal of Anesthesia·Tarun BhallaJoseph D Tobias
Mar 16, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ken Gillman
Aug 21, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Joanne L C TanMarco Fedi
May 3, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·V ChhorT Lescot
Jan 23, 2016·Autonomic Neuroscience : Basic & Clinical·William P Cheshire
Sep 25, 2012·Critical Care Clinics·Matthew W Hedge
Jul 29, 2010·Pharmacoepidemiology and Drug Safety·P Ken Gillman
Oct 1, 2011·Journal of Clinical Pharmacology·Peter KreuzerBerthold Langguth
Mar 23, 2011·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Jennifer L Lyons, Adam B Cohen
Sep 4, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Michael J BossColleen Koch
Jan 15, 2013·General Hospital Psychiatry·Faruk Uguz, Erdem Önder Sonmez
May 24, 2016·Rinshō shinkeigaku = Clinical neurology·Yuji ShigaMasaru Kuriyama
May 22, 2010·Journal of Psychopharmacology·P Ken Gillman
Jan 1, 2012·The Neurohospitalist·Odinachi Oguh, Aleksandar Videnovic
Jul 29, 2011·Medicine, Science, and the Law·P Ken Gillman
May 20, 2016·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Scott CherryPriyangika Halangoda
Dec 25, 2012·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Megan E Musselman, Suprat Saely
May 23, 2019·International Journal of Psychiatry in Clinical Practice·Tevfik KaleliogluMurat Emul
Jul 2, 2015·American Journal of Therapeutics·Ami SchattnerJoel D Cohen
Mar 31, 2016·Movement Disorders Clinical Practice·Roopa RajanAsha Kishore
Aug 3, 2012·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·René Ernst NielsenJimmi Nielsen

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