PMID: 6108981Jan 1, 1981Paper

Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients

The Journal of Nervous and Mental Disease
L E TuneS H Snyder

Abstract

Serum neuroleptic levels and clinical response have been compared serially in 10 schizophrenic patients treated with a variety of neuroleptics using a novel radioreceptor assay for neuroleptics. In this assay the drug in serum completes with [3H]spiroperidol for binding to dopamine receptors on membranes of the caudate nucleus. Serum neuroleptic levels, expressed in terms of dopamine receptor occupancy, were similar for most neuroleptics at therapeutic doses. Thioridazine levels were substantially higher than those of other neuroleptics.

Citations

Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·J L SantosJ A Cabranes
Jan 1, 1982·Acta Pharmacologica Et Toxicologica·M LinnoilaR J Wyatt
Oct 1, 1993·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·M A GagnéT Di Paolo
Apr 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·J TurbottL Hunter

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