Neuroleptics antagonize nalbuphine antianalgesia

The Journal of Pain : Official Journal of the American Pain Society
R W GearJon Levine

Abstract

To evaluate the role of sigma receptors in the sexually dimorphic antianalgesic effect of agonist-antagonist kappa opioids, 2 neuroleptics, haloperidol, a sigma receptor antagonist, and chlorpromazine, which has minimal effect at sigma receptors, were administered with the agonist-antagonist kappa opioid nalbuphine in patients with postoperative pain. Before surgical extraction of bony impacted mandibular third molar teeth, patients received haloperidol (1 mg), chlorpromazine (10 mg), or placebo by oral administration. After surgery, the pain intensity did not differ significantly between the 3 treatment groups, suggesting lack of analgesic effect produced by either haloperidol or chlorpromazine. All patients were then administered nalbuphine (5 mg, intravenous). As previously reported, the group that did not receive a preoperative neuroleptic exhibited sexually dimorphic analgesia, with women experiencing greater analgesia than men. Antianalgesia was also observed, with men experiencing late onset increased pain compared with baseline, starting approximately 1 hour after nalbuphine administration. Both neuroleptics blocked nalbuphine antianalgesia, resulting in enhanced analgesia and elimination of the sex differences. Because...Continue Reading

References

Nov 1, 1988·The Journal of Clinical Investigation·J D LevineT J Coderre
Aug 1, 1983·Japanese Journal of Pharmacology·M TeraiH Maeno
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S W Tam, L Cook
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S W Tam
Aug 1, 1994·Journal of Pain and Symptom Management·J FaucettJ Levine
Nov 30, 1993·European Journal of Pharmacology·C C Chien, G W Pasternak
Nov 1, 1995·Neuroscience·N C GordonJ D Levine
Mar 1, 1996·Neuroscience Letters·R W GearJ D Levine
Mar 6, 2003·Neuroscience Letters·Robert W GearJon D Levine
Apr 29, 2004·Anesthesiology·Roger B FillingimRoland Staud
Aug 25, 2004·European Journal of Pain : EJP·Roger B Fillingim, Robert W Gear

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Citations

Jul 6, 2014·Best Practice & Research. Clinical Anaesthesiology·Blas CatalaniAlan David Kaye
Dec 24, 2008·Women's Health·Jen Richardson, Anita Holdcroft
Jun 4, 2015·Expert Opinion on Investigational Drugs·José Miguel VelaCarmen Almansa
Feb 12, 2008·Life Sciences·Orazio PrezzaventoGiuseppe Ronsisvalle
Oct 24, 2007·Peptides·Richard J Bodnar
Oct 19, 2010·Life Sciences·Khampaseuth Rasakham, Lee-Yuan Liu-Chen
Mar 19, 2013·European Journal of Pharmacology·Daniel ZamanilloJosé Miguel Vela

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