PMID: 8968450Dec 1, 1996Paper

Neuroleptics in acute mania: a pharmacoepidemiologic study

The Annals of Pharmacotherapy
J C ChouP Czobor

Abstract

To provide an epidemiologic descriptive analysis of the acute drug treatment of inpatients with bipolar mania in state psychiatric facilities in 1990. We surveyed the first 3 weeks of drug treatment of all inpatients with bipolar mania who were admitted to 22 New York State adult psychiatric facilities during a 6-month period (n = 528). Almost all patients with mania were treated with neuroleptics. The mean +/- SD neuroleptic dosage was 684 +/- 543 mg/d chlorpromazine equivalents. Sixty-one percent of the patients received lithium and 12% received carbamazepine or valproate. Neuroleptic dosage was related to age, with older patients receiving lower dosages. Patients receiving combination treatment of a neuroleptic with either lithium, an anticonvulsant, or a benzodiazepine received a mean neuroleptic dosage similar to that of patients treated with a neuroleptic alone. Although their use has been widely discouraged for mood disorders, neuroleptics have been the standard treatment for acute mania.

Citations

May 5, 2001·Expert Opinion on Pharmacotherapy·S Watson, A H Young
Jul 31, 2001·Journal of Clinical Psychopharmacology·J C ChouJ Volavka
Aug 4, 2004·International Clinical Psychopharmacology·Dimitris SamellasJohn C Cookson
Aug 3, 2012·Expert Review of Neurotherapeutics·Helena Kyunghee Kim, Ana Cristina Andreazza
Mar 10, 2001·International Clinical Psychopharmacology·R W LichtH Christensen
Dec 10, 1999·Journal of Clinical Psychopharmacology·J C ChouJ Volavka
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·S F McTavishP J Cowen
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Nov 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nikhil M UrsMarc G Caron

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