Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia

Glia
M GilbertVanessa J Auld

Abstract

The molecular mechanisms that drive glia-glial interactions and glia-neuronal interactions during the development of the nervous system are poorly understood. A number of membrane-bound cell adhesion molecules have been shown to play a role, although the precise nature of their involvement is unknown. One class of molecules with cell adhesive properties used in the nervous system is the serine-esterase-like family of transmembrane proteins. A member of this class, a glia-specific protein called gliotactin, has been shown to be necessary for the development of the glial sheath in the peripheral nervous system of Drosophila melanogaster. Gliotactin is essential for the development of septate junctions in the glial sheath of individual and neighboring glia. Mutations that remove this protein result in paralysis and eventually death due to a breakdown in the glial-based blood-nerve barrier. To study the role of gliotactin during vertebrate nervous system development, we have isolated a potential vertebrate gliotactin homologue from mice and rat and found that it corresponds to neuroligin 3. Using a combination of RT-PCR and immunohistochemistry, we have found that neuroligin 3 is expressed during the development of the nervous syst...Continue Reading

References

Jul 1, 1992·Journal of Neurocytology·K R HuxlinJ H Furby
Dec 1, 1991·Cellular and Molecular Neurobiology·P V SarthyJ Huang
Oct 15, 1991·The Journal of Comparative Neurology·R Doucette
Aug 15, 1989·The Journal of Comparative Neurology·T L LingJ Stone
Nov 8, 1986·The Journal of Comparative Neurology·C Van HartesveldtB K Hartman
May 5, 1995·Cell·K IchtchenkoT C Südhof
Feb 2, 1996·The Journal of Biological Chemistry·K IchtchenkoT C Südhof
Jul 1, 1996·Vision Research·J M RamírezJ García-Sánchez
Jul 17, 1998·Brain Research Bulletin·A Ramón-Cueto, J Avila
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·J Y SongN Brose
Mar 25, 2000·Science·M D AdamsJ C Venter

❮ Previous
Next ❯

Citations

Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·B W Jones
Dec 18, 2001·Journal of Neurobiology·M Z LevineC D Derby
Oct 31, 2003·Trends in Neurosciences·Francisco G Scholl, Peter Scheiffele
Jul 16, 2008·The Australian and New Zealand Journal of Psychiatry·Maxwell R Bennett A O
Feb 7, 2009·Journal of Neurotrauma·Michael D KawajaRon Doucette
Sep 25, 2012·Journal of Neuroinflammation·Fujiang CaoXiaohong Li
Nov 1, 2008·PloS One·Sunita BiswasCharles Claudianos
Feb 11, 2014·Neural Plasticity·Yann BernardinelliIrina Nikonenko
Sep 8, 2010·Cellular and Molecular Life Sciences : CMLS·Floriano RodriguesChristian Klämbt
Mar 12, 2011·Cellular and Molecular Life Sciences : CMLS·Alessia BottosMarco Arese
Apr 6, 2013·Neurochemical Research·Marie Louise Bang, Sylwia Owczarek
Jul 13, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jose RussoIrma H Russo
Jun 5, 2003·The Journal of Cell Biology·Jennifer L Genova, Richard G Fehon
Feb 28, 2003·Journal of Neuroscience Research·M Teresa Moreno-FloresFrancisco Wandosell
Dec 14, 2007·The Journal of Comparative Neurology·Karl J WahlinRuben Adler
Sep 28, 2007·The European Journal of Neuroscience·Elaine C Budreck, Peter Scheiffele
Oct 30, 2010·The Journal of Comparative Neurology·Karl J WahlinDonald J Zack
Dec 25, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Alberto RissoneFranco Cotelli
Dec 27, 2005·Trends in Neurosciences·Marc R Freeman, Johnna Doherty
Dec 13, 2005·Trends in Neurosciences·Camin Dean, Thomas Dresbach
Oct 16, 2013·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mona H HaronAsok K Dasmahapatra
Nov 9, 2001·Annual Review of Genetics·U TepassR Fehon
Jan 11, 2002·Developmental Biology·K J SeppV J Auld
Oct 26, 2005·Neuron·Joshua N Levinson, Alaa El-Husseini
Apr 22, 2015·Neurodegenerative Disease Management·Ikhlas A Sindi, Peter R Dodd
Apr 4, 2015·BioMed Research International·Xiaoge HuJunyu Xu
Dec 4, 2014·Journal of Molecular Neuroscience : MN·Chen ShenNanbert Zhong
Nov 12, 2013·Neurobiology of Aging·Ikhlas A SindiPeter R Dodd
Jan 22, 2019·Translational Psychiatry·Sven O BachmannStéphane J Baudouin
Mar 31, 2005·The Journal of Biological Chemistry·Alexander A ChubykinThomas C Südhof
Jul 4, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michelle D GjørlundVladimir Berezin
Oct 3, 2003·The Journal of Biological Chemistry·Davide ComolettiPalmer Taylor
Feb 23, 2020·Cellular and Molecular Life Sciences : CMLS·Liming QinBo Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.