Neurolinguistic features of spontaneous language production dissociate three forms of neurodegenerative disease: Alzheimer's, Huntington's, and Parkinson's.

Brain and Language
J Illes

Abstract

An analysis of the temporal (prospective) form (silent and filled hesitations, repetitions, incomplete phrases, context-related comments, interjections), syntactic form, and lexical (retrospective) form (verbal deviations, open and closed class phrases) of spontaneous language production of early and middle stage Alzheimer's, Huntington's, and Parkinson's patients was made. Results showed that the language structure was disrupted in each disease, but in different ways. Temporal interruptions of varying types were frequent in the language of Alzheimer's and Huntington's Disease patients; only long-duration silent hesitations were frequent in Parkinson's language samples. Syntactic complexity was reduced in Huntington's Disease. Verbal paraphasias were found in both the language of Alzheimer's patients, as well as moderately advanced Huntington's patients. Closed class phrases were predominant in the language of Alzheimer's patients and Huntington's patients, and open class phrases in the language of Parkinson's patients. Taken together, the results suggest that (1) there is a unique neurolinguistic profile for spontaneous language production for each neurodegenerative disease, (2) pathology of the neostriatum disrupts syntactic ...Continue Reading

References

Jul 1, 1977·Brain and Language·L K Obler, M L Albert
Jan 1, 1976·Annals of the New York Academy of Sciences·K H Pribram
May 1, 1985·Brain and Language·D B HierA G Shindler
May 1, 1985·Brain and Language·K A BaylesK K Eagans
Oct 1, 1986·Journal of Communication Disorders·E J Metter, W R Hanson
Nov 1, 1967·The Journal of Speech and Hearing Disorders·M Berman, L M Peelle
Nov 1, 1980·Neurology·M P Alexander, S R LoVerme
May 1, 1983·Brain and Language·K A Bayles, C K Tomoeda
Jul 1, 1983·Clinical Pharmacokinetics·A J Cummings
Jan 1, 1982·Brain and Cognition·F J PirozzoloM A Kuskowski
Jan 1, 1982·Archives of Neurology·A R DamasioF Gersh
Sep 1, 1982·The American Journal of Psychiatry·B ReisbergT Crook
Jul 1, 1982·Brain and Language·K A Bayles
May 1, 1982·The Journal of Speech and Hearing Disorders·K A Bayles, D R Boone
Sep 1, 1980·Brain and Language·Y JoanetteA R Lecours

❮ Previous
Next ❯

Citations

Jan 20, 2009·The Journal of Nutrition, Health & Aging·E G Visch BrinkT J M Van der Cammen
Oct 5, 2001·Neuropsychologia·M Grossman, J Rhee
Oct 9, 1999·Progress in Neurobiology·E BrouilletP Hantraye
Oct 10, 2008·Brain : a Journal of Neurology·R De Diego-BalaguerA-C Bachoud-Lévi
Sep 23, 2006·Journal of Cognitive Neuroscience·Marc TeichmannAnne-Catherine Bachoud-Lévi
Jul 1, 1996·The International Journal of Neuroscience·P McNamaraR Durso
Sep 8, 2012·Clinical Linguistics & Phonetics·Sarah VanhouttePatrick Santens
Nov 18, 2010·Clinical Linguistics & Phonetics·Frederique GayraudMelissa Barkat-Defradas
Apr 13, 2010·International Journal of Speech-language Pathology·Ildikó HoffmannJános Kálmán
Apr 28, 2012·Brain and Language·Dezso NemethMichael T Ullman
Mar 24, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Katrien S F ColmanRoelien Bastiaanse
Oct 27, 1997·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·D NatsopoulosG Mentenopoulos
Aug 24, 2011·Parkinson's Disease·Lori J P Altmann, Michelle S Troche
Aug 31, 2001·Brain and Cognition·L L Murray, L P Lenz
May 1, 1992·Brain and Language·M GrossmanH I Hurtig
Jan 10, 2002·Brain and Language·S E Nadeau
Jun 1, 1997·Brain and Language·L J Garcia, Y Joanette
Nov 22, 2011·Brain and Language·Sharon AshMurray Grossman
May 17, 2017·Current Opinion in Neurology·Clara Garcia-GorroRuth de Diego-Balaguer
Oct 28, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Sarah J Getz, Bonnie Levin
Mar 2, 2018·Clinical Linguistics & Phonetics·Jessica DickJiyeon Lee
Sep 13, 2018·Journal of Speech, Language, and Hearing Research : JSLHR·Angela Roberts, Danielle Post
Dec 19, 2018·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Maude GagnonJoël Macoir
Jul 18, 2015·Journal of Speech, Language, and Hearing Research : JSLHR·Diana Van Lancker SidtisJohn J Sidtis
Feb 24, 2001·Journal of Speech, Language, and Hearing Research : JSLHR·L L Murray
Apr 7, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Jiyeon Lee
Mar 23, 2017·Frontiers in Psychology·Veronica BoschiStefano F Cappa
Jul 6, 2019·Frontiers in Psychology·Sonia MontemurroGiorgio Arcara
Mar 25, 2005·Brain : a Journal of Neurology·Marc TeichmannAnne-Catherine Bachoud-Lévi
Aug 9, 2018·Frontiers in Neurology·Diana Van Lancker Sidtis, John J Sidtis
Feb 1, 1995·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S Furtado, O Suchowersky
Sep 17, 2021·Journal of Speech, Language, and Hearing Research : JSLHR·Chorong OhXianhui Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.