Neurologic complications in patients with inflammatory bowel disease: increasing relevance in the era of biologics

Inflammatory Bowel Diseases
Siddharth SinghSunanda V Kane

Abstract

Extraintestinal manifestations of inflammatory bowel disease (IBD) can involve almost every organ system. Neurologic complications are not infrequent in patients with IBD, but are poorly recognized and underreported. Pathophysiologically, these may represent immune-mediated phenomenon, nonimmunologic complications due to micronutrient deficiencies, thromboembolism, or be medication-induced. Peripheral neuropathy is the most common neurologic complication of IBD and may be immune-mediated, or caused by therapy with anti-tumor necrosis factor-alpha (TNF-α) therapy or metronidazole. Multiple sclerosis occurs with a greater frequency in patients with IBD. Anti-TNF-α therapy can cause neurologic disease characterized by central demyelination that mimics multiple sclerosis. Hence, patients with a history of demyelinating diseases or with symptoms of polyneuropathy should be carefully evaluated before initiation of anti-TNF-α therapy. Natalizumab has been associated with fatal progressive multifocal leukoencephalopathy due to reactivation of JC virus, and occurs with greater frequency in patients with previous JC virus infection. Stroke secondary to venous or arterial thromboembolism can be seen in patients with active Crohn's disease...Continue Reading

References

Feb 1, 1991·Scandinavian Journal of Gastroenterology·D StåhlbergA Persson
Apr 1, 1991·Scandinavian Journal of Gastroenterology·S LindgrenG Sundkvist
Mar 1, 1985·Gastroenterology·L F DuffyM Silverberg
Oct 1, 1987·The New England Journal of Medicine·P C de GroenR A Krom
Jul 1, 1984·Annals of Internal Medicine·S R Snavely, G R Hodges
Mar 1, 1995·Neurology·A LossosI Steiner
Jul 1, 1993·Scandinavian Journal of Gastroenterology·S LindgrenG Sundkvist
May 1, 1996·Gut·J SatsangiD P Jewell
Jun 1, 1997·Southern Medical Journal·A Elsehety, T E Bertorini
Jul 10, 1999·Journal of Neurology·J M GijtenbeekC J Vecht
Aug 16, 2000·Mayo Clinic Proceedings·K KimuraS F Phillips
Nov 13, 2002·Arthritis and Rheumatism·Tom W J HuizingaRudi G J Westendorp
Jan 3, 2003·The New England Journal of Medicine·Subrata GhoshUNKNOWN Natalizumab Pan-European Study Group
Dec 23, 2003·The American Journal of Gastroenterology·Craig A SolemWilliam J Sandborn
Feb 12, 2005·Brain : a Journal of Neurology·F A A GondimN Latov
Jun 11, 2005·The New England Journal of Medicine·Annette Langer-GouldDaniel Pelletier
Nov 4, 2005·The New England Journal of Medicine·William J SandbornUNKNOWN Evaluation of Natalizumab as Continuous Therapy (ENACT-2) Trial Group
Feb 25, 2006·Nature Reviews. Immunology·David H Adams, Bertus Eksteen
Mar 15, 2006·Inflammatory Bowel Diseases·Jérôme FilippiStéphane M Schneider
Apr 29, 2006·Arthritis and Rheumatism·In-Sook J ShinJeffrey N Siegel
Sep 19, 2006·Best Practice & Research. Clinical Rheumatology·Sheetal B Desai, Daniel E Furst
Apr 18, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R Scheid, N Teich
Aug 19, 2007·BMC Gastroenterology·Bodil OhlssonStefan Lindgren
Nov 28, 2007·Muscle & Nerve·Joerg-Patrick Stübgen
Dec 8, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Charles N BernsteinJames F Blanchard
Jun 27, 2008·Current Treatment Options in Neurology·Allen J Aksamit
May 5, 2009·American Journal of Otolaryngology·Collin S KarmodyNikolas H Blevins
May 13, 2009·The Journal of Infectious Diseases·Adrian EgliHans H Hirsch
Jun 6, 2009·The American Journal of Gastroenterology·Christina HaChristian D Stone
Aug 15, 2009·Scandinavian Journal of Gastroenterology·Samia Ben SassiFayçal Hentati
Oct 27, 2009·Autoimmunity Reviews·Manuel Ramos-CasalsUNKNOWN BIOGEAS Study Group
Nov 26, 2009·Neurologic Clinics·Neeraj Kumar

❮ Previous
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Citations

Feb 9, 2013·Der Nervenarzt·N CieplikO Bachmann
Nov 5, 2013·World Journal of Gastroenterology : WJG·Hui WangJun-Ming Luo
Dec 5, 2013·Scandinavian Journal of Gastroenterology·Jan StovicekRadan Keil
Apr 12, 2015·Scandinavian Journal of Gastroenterology·Shinji NakamuraYoshiyuki Nakajima
Feb 5, 2014·Expert Review of Clinical Immunology·Aristeidis H Katsanos, Konstantinos H Katsanos
Apr 24, 2015·Expert Review of Gastroenterology & Hepatology·Bincy P Abraham
Jun 25, 2013·Medicina clínica·Eduardo Rubio-NazábalAntonio Brage-Varela
Feb 24, 2016·Gastroenterology Research and Practice·Ulker Anadol KelleciDestina Yalcin
Aug 27, 2015·Journal of the Peripheral Nervous System : JPNS·Pinelopi TsouniThierry Kuntzer
Aug 1, 2015·Inflammatory Bowel Diseases·Maneesh DaveWilliam A Faubion
Mar 31, 2015·Gastroenterology·Douglas A Simonetto, Konstantinos A Papadakis
May 8, 2015·European Journal of Gastroenterology & Hepatology·Patrick D HoekBen J M Witteman
Mar 6, 2015·Journal of Crohn's & Colitis·Konstantinos KarmirisUNKNOWN ECCO CONFER investigators
Apr 7, 2016·Journal of Pediatric Gastroenterology and Nutrition·Scott B RaymondKatherine Nimkin
Mar 6, 2015·Arquivos de neuro-psiquiatria·Francisco de Assis Aquino GondimErick L Messias
Apr 5, 2014·Journal of Child Neurology·Orly Ben-OrAaron Lerner
Jul 15, 2015·Inflammatory Bowel Diseases·Stephan R VavrickaGerhard Rogler
Apr 6, 2018·Journal of Pediatric Gastroenterology and Nutrition·Jessica BretonColette Deslandres
Jul 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Claudia Ott, Jürgen Schölmerich
Feb 12, 2020·Journal of Pediatric Gastroenterology and Nutrition·Valérie BertrandUNKNOWN GETAID (Groupe d’Etude thérapeutique des Affections Inflammatoires du Tube Digestif) pédiatrique
Nov 24, 2016·Journal of Neurology·Maria KosmidouSotirios Giannopoulos
Aug 7, 2019·International Journal of Immunopathology and Pharmacology·Sana ChamsInaya Hajj Hussein
May 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Valérie BertrandUNKNOWN GETAID (Groupe d’Etude thérapeutique des Affections Inflammatoires du Tube Digestif) Pdiatrique
Aug 3, 2020·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Cynthia MorvilloSteven Stein
Jan 31, 2017·Current Opinion in Gastroenterology·Maneesh DaveFabio Cominelli
Jul 12, 2019·Journal of the Canadian Association of Gastroenterology·Charles N BernsteinGilaad G Kaplan
Mar 25, 2017·Current Neurology and Neuroscience Reports·Elissavet Kemanetzoglou, Elisabeth Andreadou
Aug 16, 2019·Gastroenterology Report·Reza NematiMajid Assadi
Apr 3, 2019·Case Reports in Rheumatology·Paul T Parks, Alexander S Easton
Jan 21, 2017·Alimentary Pharmacology & Therapeutics·G ConwayA N Ananthakrishnan
Aug 28, 2021·International Journal of Molecular Sciences·Claudia GüntherBeate Winner

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