Neurologic complications of chemotherapy and other newer and experimental approaches

Handbook of Clinical Neurology
Riccardo SoffiettiRoberta Rudà

Abstract

Neurologic complications of conventional cytototxic agents as well as those from monoclonal antibodies and targeted therapies are increasingly observed in patients with cancer. The major categories are represented by alkylating agents (platinum compounds, ifosfamide, procarbazine, thiotepa), mitotic spindle inhibitors (vinca alkaloids, taxanes, etoposide, teniposide), proteasome inhibitors (bortezomib), antibiotics, antimetabolites, thalidomide, lenalidomide, topoisomerase inhibitors, interferon-α, hormones, bevacizumab, trastuzumab, and small tyrosine kinase inhibitors. Peripheral neuropathy is a common adverse effect of a number of chemotherapeutic drugs and often represents a critical factor limiting an adequate dose-intensity of chemotherapy. Regarding the central nervous system (CNS), it is vulnerable to many forms of toxicity from chemotherapeutic agents, including encephalopathy syndromes and confusional states, seizures, headache, cerebrovascular complications, visual loss, cerebellar syndromes, and myelopathy. For a given drug, the occurrence of CNS toxicity depends on several factors, including the total dose, route of administration, presence of structural brain lesions, exposure to prior or concurrent irradiation, a...Continue Reading

Citations

Mar 7, 2018·BMJ Case Reports·Rola A Mahmoud, Charles K Abrams
Sep 24, 2015·Nature Reviews. Clinical Oncology·Jacqueline B Stone, Lisa M DeAngelis
Jan 1, 2016·Nature Reviews. Clinical Oncology·Helen Gharwan, Hunter Groninger
Nov 23, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Alaa Abd-Elsayed, Natalie Pahapill
Nov 3, 2016·Current Opinion in Neurology·Craig Nolan, Lisa M DeAngelis
May 26, 2018·Pediatric Blood & Cancer·Takashi MikamiSouichi Adachi
Jan 23, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·E García Molina, M Penas-Prado
Aug 28, 2020·Neurochemistry International·Dia AdvaniPravir Kumar
Jun 7, 2021·Research in Veterinary Science·E P G VaziE F Bondan

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