PMID: 9188597Jul 1, 1997Paper

Neurologic disease induced by polytropic murine retroviruses: neurovirulence determined by efficiency of spread to microglial cells

Journal of Virology
S J RobertsonJ L Portis

Abstract

Several murine leukemia viruses (MuLV) induce neurologic disease in susceptible mice. To identify features of central nervous system (CNS) infection that correlate with neurovirulence, we compared two neurovirulent MuLV, Fr98 and Fr98/SE, with a nonneurovirulent MuLV, Fr54. All three viruses utilize the polytropic receptor and are coisogenic, each containing a different envelope gene within a common genetic background. Both Fr98 and Fr98/SE induce a clinical neurologic disease characterized by hyperexcitability and ataxia yet differ in incubation period, 16 to 30 and 30 to 60 days, respectively. Fr54 infects the CNS but fails to induce clinical signs of neurologic disease. In this study, we compared the histopathology, regional virus distribution, and cell tropism in the brain, as well as the relative CNS viral burdens. All three viruses induced similar histopathologic effects, characterized by intense reactive astrogliosis and microglial activation associated with minimal vacuolar degeneration. The infected target cells for each virus consisted primarily of endothelial and microglial cells, with rare oligodendrocytes. Infection localized predominantly in white matter tracts of the cerebellum, internal capsule, and corpus callo...Continue Reading

References

Apr 1, 1979·European Journal of Immunology·T SpringerC Milstein
Nov 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R T JohnsonO Narayan
Jun 1, 1986·Annals of Neurology·B A NaviaR W Price
Oct 1, 1973·Journal of the National Cancer Institute·M B GardnerR J Huebner
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Feb 1, 1974·The Journal of Infectious Diseases·L C CorkR C Piper
Mar 1, 1994·Journal of Neuropathology and Experimental Neurology·D M RauschL E Eiden
May 1, 1994·The Journal of General Virology·T R PhillipsJ H Elder
May 1, 1994·Journal of Neuropathology and Experimental Neurology·C L AchimC A Wiley

❮ Previous
Next ❯

Citations

Jun 17, 2005·Reviews in the Neurosciences·Esperanza Gomez-Lucia
Dec 10, 1999·Journal of Virology·S AskovićJ L Portis
Jan 30, 2015·The Journal of General Virology·Sandra SoutoIsabel Bandín

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.