Neurologic disorders and Hepatitis E: Review of literature

La Revue de médecine interne
A BelbezierLaurence Bouillet

Abstract

Hepatitis E is an emerging, worldwide disease. It is often asymptomatic. Nevertheless, in few cases, clinical manifestation such as neurological disorder could be present. The aim of this article is to realize a literature review of the neurological symptoms associated with hepatitis E. We searched the Pubmed database using the term "hepatitis E", "neurological disorder AND hepatitis E". One hundred and thirty cases have been described between 2000 and 2017. The majority of cases were associated with the genotype 3 and were reported in Europe or in Asia. It preferentially affected immunocompetent (93%) men with a median age of 52 years. The main neurologic disorders were Guillain-Barré syndrome (54 cases), Parsonage-Turner syndrome (35 cases), multiplex mononeuropathy (6 cases), meningitis and meningoencephalitis (9 cases). The diagnosis was done with HEV IgM serology in most cases (98%). Aminotranferases increase and cholestasis were found in 88% and 82% respectively. The outcome varied according to the neurological syndrome. Antiviral or immunomodulatory therapies did not seem to improve symptoms. Hepatitis E seems to be associated with acute, wide neurological disorders. These data should be confirmed with a long term prospe...Continue Reading

Citations

Nov 25, 2020·Journal of Medical Virology·Cosme Alvarado-EsquivelAntonio Sifuentes-Alvarez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Anaïs DartevelLaurence Bouillet
Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
A DerouxP Pavese
The American Journal of Gastroenterology
A SoodN Sood
The New England Journal of Medicine
I C PLOUGH, R S AYERLE
© 2022 Meta ULC. All rights reserved