Neurologic dysfunction in hypothyroid, hyperlipidemic Labrador Retrievers

Journal of Veterinary Internal Medicine
Christina L Vitale, Natasha J Olby

Abstract

Hypothyroidism has been associated with a variety of neurologic signs, but the mechanism for this association is not completely understood. Hypothyroidism also is associated with hyperlipidemia that predisposes to atherosclerosis, increased blood viscosity, and thromboembolic events. The objective is to characterize neurologic signs potentially associated with hyperlipidemia and atherosclerosis in canine hypothyroidism. This study used dogs referred to North Carolina State University Veterinary Teaching Hospital for evaluation of neurologic signs. A retrospective study was conducted in which medical records of dogs with neurologic signs and a diagnosis of hypothyroidism and hyperlipidemia were reviewed. Details of the history, presenting signs, results of routine blood tests, thyroid tests, cerebrospinal fluid (CSF) analysis and diagnostic imaging, and response to therapy were compiled. Three Labrador Retrievers and one Labrador Retriever cross fit the inclusion criteria. All dogs were hypothyroid and severely hyperlipidemic. Neurologic signs included tetraparesis, central and peripheral vestibular signs, facial paralysis, and paraparesis. Two dogs had an acute history and rapid resolution of signs consistent with an infarct, t...Continue Reading

Citations

Dec 3, 2008·Journal of the American Veterinary Medical Association·Bianca C SchwarzBarbara Nell
May 12, 2016·The Journal of Small Animal Practice·A JeandelS Blot
Dec 1, 2009·The Veterinary Journal·Marc KentScott J Schatzberg
Jan 27, 2009·The Veterinary Journal·Panagiotis G Xenoulis, Jörg M Steiner
Sep 30, 2010·Veterinary Clinical Pathology·Theresa PancottoKurt L Zimmerman
Oct 13, 2015·The Journal of Small Animal Practice·P G Xenoulis, J M Steiner
Feb 9, 2017·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Roser Tetas PontElsa Beltran
Nov 6, 2012·The Journal of Veterinary Medical Science·Masaya TsuboiHiroyuki Nakayama

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