Neurologic dysfunctions caused by a molecular clone of feline immunodeficiency virus, FIV-PPR

Journal of Neurovirology
T R PhillipsS J Henriksen

Abstract

FIV is a lentivirus of domestic cats that causes a spectrum of diseases that is remarkably similar to the clinical syndrome produced by HIV infection in people. Both HIV and FIV has been shown to cause neurologic dysfunction. Specific Pathogen-Free (SPF) cats were placed into one of three groups: FIV-PPR infected; DU-FIV-PPR (a dUTPase mutant of the FIV-PPR clone) infected; or an age-matched control group. In both infected groups, the general clinical signs of infection included lymphadenopathy, oral ulcerations, rough hair coat, and conjuntivitis. Specific neurological changes in the FIV-PPR infected cats included hind limb paresis; delayed righting and pupillary reflexes; behavioral changes; delayed visual and auditory evoked potentials; decreased spinal and peripheral nerve conduction velocities; and marked alterations in sleep patterns. Most of these changes were also observed in the DU-FIV-PPR infected cats. However, these cats tended to have a slightly less severe disease. In this study, we have demonstrated that an infectious molecular clone of FIV closely parallels the disease course of wild type FIV-infected cats. By using a knockout gene mutant of this clone, we were able to demonstrate that the dUTPase gene is not es...Continue Reading

Citations

Dec 8, 1998·Muscle & Nerve·M PodellG D Shelton
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rick B Meeker
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Yuri Persidsky, Howard Fox
Jun 2, 2009·Journal of Feline Medicine and Surgery·Margaret J HosieMarian C Horzinek
Nov 9, 2011·Journal of Feline Medicine and Surgery·Holger A VolkKaspar Matiasek
Jan 8, 1999·Brain Research·D C BraggM B Tompkins
Mar 14, 2001·Drug and Alcohol Dependence·O BilletT R Phillips
Sep 23, 2000·Veterinary Microbiology·R M HokansonE W Collisson
Jul 13, 2002·Bioorganic & Medicinal Chemistry Letters·Sanjay K SharmaJ William Lown
Nov 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chris K GrantJohn H Elder
Apr 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·N YuT R Phillips
Feb 13, 2002·AIDS Research and Human Retroviruses·Mary Jo BurkhardEdward A Hoover
Oct 17, 2006·Clinical Microbiology Reviews·Sue VandeWoude, Cristian Apetrei
Nov 2, 2011·The Veterinary Clinics of North America. Small Animal Practice·Joanna WhiteJacqueline M Norris
Jul 5, 2011·Veterinary Immunology and Immunopathology·Jennifer L TroyerStephen J O'Brien
Jul 1, 2011·Veterinary Immunology and Immunopathology·Craig MillerSusan VandeWoude
Oct 12, 2004·The Veterinary Clinics of North America. Small Animal Practice·Peter J Dickinson, Richard A LeCouteur
Apr 27, 2010·The Veterinary Journal·Nicola F FletcherJohn J Callanan
Aug 12, 2015·Retrovirology·Amnon Hizi, Eytan Herzig
Jan 1, 1997·Neurobiology of Disease·H S FoxF E Bloom
Dec 6, 2000·Journal of Psychopharmacology·M PodellL E Mathes
Feb 10, 2016·JFMS Open Reports·Lorenzo MariLuisa De Risio
Apr 21, 2018·Viruses·Craig MillerSue VandeWoude
Jan 1, 1997·Critical Reviews in Biotechnology·F Clementi
Mar 9, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·A J PhippsL E Mathes
Aug 31, 2000·Neurobiology of Disease·M Sánchez-AlavezO Prospéro-García
Feb 22, 2008·Veterinary Immunology and Immunopathology·John H ElderYing-Chuan Lin

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