Neurologic manifestations of acute liver failure

Handbook of Clinical Neurology
Sudhir Datar, Eelco F M Wijdicks

Abstract

Fulminant hepatic failure presents with a hepatic encephalopathy and may progress to coma and often brain death from cerebral edema. This natural progression in severe cases contributes to early mortality, but outcome can be good if liver transplantation is appropriately timed and increased intracranial pressure (ICP) is managed. Neurologists and neurosurgeons have become more involved in these very challenging patients and are often asked to rapidly identify patients who are at risk of cerebral edema, to carefully select the patient population who will benefit from invasive ICP monitoring, to judge the correct time to start monitoring, to participate in treatment of cerebral edema, and to manage complications such as intracranial hemorrhage or seizures. This chapter summarizes the current multidisciplinary approach to fulminant hepatic failure and how to best bridge patients to emergency liver transplantation.

Citations

Mar 13, 2017·Transplantation Reviews·Paolo FeltraccoCarlo Ori
Aug 31, 2014·Current Neurology and Neuroscience Reports·José M Ferro, Sofia Oliveira
May 12, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexandra S ReynoldsNeha S Dangayach
Jun 18, 2016·Current Treatment Options in Neurology·José M FerroPatrícia Santos
Jul 20, 2018·Journal of Microscopy and Ultrastructure·Paul F Seke EtetLorella Vecchio

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