Neurologic manifestations of antiphospholipid syndrome

Lupus
I F RicarteDanieli Castro Oliveira de Andrade

Abstract

Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome, transverse myelitis and ocular symptoms. Most neurological manifestations are associated with thrombosis of the microcirculation or of large vessels; nonetheless, there is compelling evidence suggesting that, in some cases, symptoms are secondary to an immune-mediated pathogenesis, with direct binding of aPL on neurons and glia. Herein we describe clinical characteristics and management of neurological APS manifestations.

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Feb 14, 2019·Lupus·I F RicarteG S Silva
Dec 12, 2018·Frontiers in Neurology·Thomas FleetwoodCristoforo Comi
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Jul 1, 2020·Terapevticheskiĭ arkhiv·A B BorisovaE L Nasonov

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Methods Mentioned

BETA
biopsy

Software Mentioned

pAPS

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