Neurologic outcomes after extracorporeal membrane oxygenation assisted CPR for resuscitation of out-of-hospital cardiac arrest patients: A systematic review

Resuscitation
Michael M BeyeaA Dave Nagpal

Abstract

Extracorporeal membrane oxygenation-assisted CPR (ECPR) is an evolving adjunct for resuscitation of OHCA patients. The primary objective of this systematic review was to assess survival-to-hospital discharge with good neurologic recovery after OHCA among patients treated with ECPR compared to conventional CPR (CCPR). A systematic search of MEDLINE® and EMBASE® electronic databases was performed from inception until July 2016 to identify studies reporting ECPR use in adults with OHCA and survival outcomes. Of the 1512 citations identified, 75 studies met our inclusion criteria (63 case series and 12 cohort studies). Among case series, 0 to 71.4% of patients treated with ECPR survived to discharge with a good neurologic outcome. Subgroup analysis of the cohort studies demonstrated survival-to-hospital discharge with good neurologic recovery in the ECPR group ranging from 8.3 to 41.6% compared to 1.5 to 9.1% in the CCPR group. Five cohort studies adjusted for confounders, 3 of which demonstrated significantly increased adjusted odds ratios of survival among the ECPR-treated patients. Due to significant heterogeneity (I2 = 63%, p = 0.03), pooling of outcomes and a meta-analysis were not conducted. Although a trend towards improved ...Continue Reading

Citations

Oct 11, 2019·Critical Care Medicine·Sung-Min ChoRomergryko G Geocadin
Mar 25, 2020·Journal of the American Heart Association·Akihiko InoueYasuhiro Kuroda
Jun 12, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Naoto MurakamiTetsuji Miura
Nov 24, 2019·Current Cardiology Reports·Sean M BellRavi S Hira
Jun 25, 2020·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Fu-Yuan SiaoHsu-Hen Yen
Aug 19, 2020·Critical Care : the Official Journal of the Critical Care Forum·Benjamin Yaël GravesteijnSanne Elisabeth Hoeks
Jan 30, 2019·Critical Care : the Official Journal of the Critical Care Forum·Daniel PatricioFabio Silvio Taccone
Sep 19, 2019·Journal of Cardiothoracic and Vascular Anesthesia·Suneel Ramesh Desai, Nian Chih Hwang
Feb 5, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Satoshi YoshimuraUNKNOWN CRITICAL Study Group Investigators
Jan 29, 2021·Journal of the American College of Emergency Physicians Open·Dennis Miraglia, Jonathan E Ayala
Oct 16, 2020·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Atsunori TanimotoYuichi Hamabe
Feb 23, 2021·Journal of the American College of Emergency Physicians Open·Dennis MiragliaWilfredo Alonso
Sep 11, 2021·Intensive Care Medicine·Darryl AbramsDaniel Brodie
May 1, 2021·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jamie E PodellGunjan Y Parikh

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