Neurological and developmental outcomes of prenatally cocaine-exposed offspring from 12 to 36 months

The American Journal of Drug and Alcohol Abuse
Marilyn W LewisTove S Rosen

Abstract

Second generation studies of prenatal cocaine exposure failed to find gross deficits after controlling for confounders. Concern remained that exposure could cause subtle deficits. This prospective, cohort study evaluated effects of cocaine on development at 12, 18, 24, and 36 months. From 1991-1993, 361 mother-infant pairs were recruited from the Children's Hospital of New York, Presbyterian Medical Center's prenatal clinic or delivery room suite. Mothers were assigned to the cocaine group based on report of prenatal cocaine use or positive urine toxicology. Control mothers were enrolled from the same clinic and matched for age and socioeconomic status (SES). Women with serious medical problems were excluded from either group. Of the retained cohort, at 12 months, 147 infants were exposed and 89 were unexposed case controls. Both groups were raised in impoverished environments with few supports. Developmental evaluations were conducted blinded to group. Cross-sectional analysis revealed cocaine-related deficits in neurological exams and speech across all time periods, in spite of catch up in weight, length, and head circumference. Overall analysis of development was evaluated using Generalized Estimating Equations regression an...Continue Reading

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Citations

Nov 7, 2006·Developmental Neuropsychology·Connie E MorrowEmmalee S Bandstra
Aug 6, 2020·International Journal of Environmental Research and Public Health·Frances M NilsenNicolle S Tulve
Mar 18, 2009·The American Journal of Orthopsychiatry·Marilyn W LewisTove S Rosen
Apr 22, 2010·Journal of Addictive Diseases·Emmalee S BandstraVeronica H Accornero
Feb 25, 2014·BMC Medicine·Andrew James LewisChristos Symeonides
Dec 13, 2006·Development and Psychopathology·Meyer D Glantz, Jessica Campbell Chambers

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