Neurological Changes in Vulnerable Brain Areas of Chronic Cerebral Hypoperfusion Mice

Annals of Neurosciences
Siriluk Somredngan, Wachiryah Thong-Asa

Abstract

Chronic cerebral hypoperfusion (CCH) is associated with neurological changes and cognitive decline. It is a major cause of vascular dementia and a contributing factor in Alzheimer disease. Animal models are useful in helping to elucidate the mechanisms of these diseases while demonstrating differences in pathological onset and severity. Furthermore, different mouse strains show differences in their susceptibility to neurological damage resulting in different cognitive outcomes. This study investigated the effect of CCH induced by permanent unilateral common carotid artery occlusion (UCO) on neurological damage in vulnerable brain regions such as hippocampus, striatum, and white matter areas from 2 to 8 weeks following CCH induction. Thirty-six male Institute of Cancer Research (ICR) mice were randomly divided into 2 main experimental groups, Sham and UCO. These 2 main groups were further divided into 3 observation periods of 2, 4, and 8 weeks following CCH. Histological study was then employed using 0.1% cresyl violet and luxol fast blue staining to assess neurological damage. We found equal levels of neurological damage induced by CCH between ipsi- and contralateral hemispheres. Hippocampus and striatum damage were slightly in...Continue Reading

Citations

Sep 8, 2020·Metabolic Brain Disease·Wachiryah Thong-AsaNutnicha Thongwan
Feb 5, 2021·Frontiers in Cell and Developmental Biology·Christina Doxaki, Konstantinos Palikaras
Aug 27, 2021·Metabolic Brain Disease·Wachiryah Thong-AsaSuchawalee Jutarattananon

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