Neurological complications in AIDS patients receiving HAART: a 2-year retrospective study

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
K SubsaiP Wantana

Abstract

The positive role of highly active anti-retroviral therapy (HAART) in reducing opportunistic infections in acquired immunodeficiency syndrome (AIDS) patients is well known. However, case reports from around the world have demonstrated that some patients seem to suffer a paradoxical deterioration of health as their immune function improves with treatment. This phenomenon has been called immune restoration inflammatory syndrome (IRIS). In northern Thailand, GPO-vir (Stavudine-D4T + Lamivudine-3TC + Nevirapine-NVP) has been promoted for the treatment of AIDS patients since April 2002, in accordance with the Government Pharmaceutical Organization's guidelines. However, the incidence rates of IRIS affecting nervous system (NIRIS) and non-NIRIS in comparison with the previous incidence of AIDS-defining disease have not been reported. We conducted a retrospective study to review the incidence of NIRIS and non-NIRIS in AIDS patients treated with GPO-vir in Chiang Mai University Hospital, Thailand, between May 2002 and April 2004. We compare these incidence rates with the incidence rates of neurological complications in the pre-HAART era. Altogether 506 AIDS patients were treated with GPO-vir during the specified period. The overall inc...Continue Reading

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Citations

Oct 4, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·D Huis in 't VeldR Colebunders
Feb 6, 2007·Modern Rheumatology·Motohisa YamamotoKohzoh Imai
Feb 9, 2012·The Indian Journal of Medical Research·Veeranoot Nissapatorn, Nongyao Sawangjaroen
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Jan 21, 2012·Cerebrovascular Diseases·Souvik SenWilliam J Powers
Apr 5, 2013·Therapeutic Advances in Chronic Disease·Elyse J SingerMargrit Carlson
Oct 10, 2009·Expert Review of Cardiovascular Therapy·Michael R Dobbs, Joseph R Berger
Oct 9, 2016·Mycopathologia·Sérgio Monteiro de Almeida, Thiago Henrique Roza
Jul 30, 2020·International Journal of Molecular Sciences·Saifudeen IsmaelTauheed Ishrat

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