Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy

International Journal of Epidemiology
Pod PharoahB S Hetzel

Abstract

Endemic cretinism is characterised by multiple neurological defects including deaf-mutism, diplegia, squint, and mental deficiency. The condition is widely prevalent in the Highlands of New Guinea in association with severe iodine deficiency. Previous studies have shown that iodised oil provides a very satisfactory correction of severe iodine deficiency in New Guinea. A controlled trial on the use of intramuscular iodised oil in the prevention of endemic cretinism was carried out in the Western Highlands of New Guinea and involved a population of approximately 8000. Subsequent follow-up over four years revealed 26 endemic cretins out of a total of 534 children born to mothers who had not received iodised oil; the mothers of 5 of these cretins were pregnant at the start of the trial. In comparison, 7 cases of endemic cretinism occurred among 498 children born to mothers who had been treated with iodised oil; in 6 of these 7 cases, the mother was pregnant when the trial commenced. It is concluded that intramuscular iodised oil is effective in the prevention of endemic cretinism and that, for it to be effective, it should be given prior to conception. This suggests that severe iodine deficiency in the mother produces neurological ...Continue Reading

References

Feb 6, 1969·The New England Journal of Medicine·R Fierro-BenítezI Ramirez
May 1, 1960·British Medical Bulletin·W R TROTTER
May 1, 1963·The Journal of Clinical Endocrinology and Metabolism·L C GALVAO LOBOD ROSENTHAL
Mar 1, 1965·The Journal of Clinical Endocrinology and Metabolism·J C CHOUFOERA QUERIDO

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Citations

Dec 18, 2015·BBA Clinical·Roy Moncayo, Karina Ortner
Aug 7, 2001·The Journal of Pediatrics·R RapaportM Freemark
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Dec 1, 2017·Frontiers in Immunology·Mahmood Y BilalKenneth D Beaman
Mar 6, 2017·The Cochrane Database of Systematic Reviews·Kimberly B HardingLuz Maria De-Regil
Jan 3, 2019·Journal of Neuroendocrinology·Mukesh KumarSubash Khushu
Sep 16, 2018·Biological Trace Element Research·Wei ZhaoCheng Han
Apr 7, 2019·Current Nutrition Reports·Davide Mattei, Angelo Pietrobelli
Jul 9, 2020·Frontiers in Endocrinology·Freddy J K TolozaSpyridoula Maraka
Feb 24, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Eduardo Rodriguez-DiazElizabeth N Pearce

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