Neurological deterioration in acute lacunar infarctions: the role of excitatory and inhibitory neurotransmitters

Stroke; a Journal of Cerebral Circulation
J SerenaA Dávalos

Abstract

The mechanisms involved in the neurological deterioration of acute lacunar strokes are unknown. Although accumulating evidence suggests that glutamate release plays a role in the progression of territorial infarctions, it remains to be established whether excitotoxicity also participates in lacunar stroke progression. We investigated whether excitatory and inhibitory amino acid concentrations in blood predict subsequent progressive motor deficits in lacunar infarctions. We studied 113 consecutive patients with lacunar infarct, defined by clinical and computed tomography/magnetic resonance imaging criteria, within the first 24 hours after stroke onset. Neurological deterioration was defined as a decrease of >/=1 points in the motor items of the Canadian Stroke Scale in the first 48 hours after admission. Glutamate, glycine, and GABA were determined by high-performance liquid chromatography in plasma samples obtained on admission. Predictive values, sensitivity, specificity, and accuracy of specific glutamate and GABA concentrations and glutamatexglycine/GABA index for progression of lacunar stroke were calculated. Twenty-seven patients (23.9%) had neurological worsening. Plasma concentrations of glutamate (253+/-70 versus 123+/-...Continue Reading

References

Jun 10, 1991·Neuroscience Letters·M Y GlobusR Busto
Dec 1, 1991·Computers and Biomedical Research, an International Journal·C RobertJ Demongeot
Dec 1, 1990·Neurology·A DávalosD Genís
Aug 1, 1982·Neurology·C M Fisher
Jan 1, 1982·Archives of Neurology·L A Weisberg
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K TakagiR Busto
Apr 30, 1998·Archives of Neurology·H YamamotoG van Melle
Jun 20, 1998·Neurology·L TatuH Duvernoy
Jan 28, 1999·Neurology·K NakamuraM Fujishima
Sep 27, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·A DávalosN G Wahlgren

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Citations

Jun 15, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Glen C Jickling, Frank R Sharp
Jan 7, 2004·Journal of the Neurological Sciences·Noriko MatsumotoKazuo Minematsu
Mar 14, 2003·Neuroscience Letters·José CastilloAntoni Dávalos
Mar 15, 2003·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Murat SumerOzcan Erturk
Jun 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S-H KohS H Kim
Sep 19, 2008·Radiation Oncology·Andrew BaschnagelKevin Camphausen
Jul 26, 2005·Neurologia Medico-chirurgica·Masahiro MishinaYasuo Katayama
Feb 8, 2013·Biomarkers in Medicine·Lena Rothstein, Glen C Jickling
Nov 12, 2005·Cerebrovascular Diseases·Stefan H KreiselMichael G Hennerici
May 3, 2006·Cerebrovascular Diseases·Mar CastellanosJosé Castillo
May 13, 2006·Cerebrovascular Diseases·Miguel BlancoJosé Castillo
May 3, 2006·Cerebrovascular Diseases·Joaquín SerenaMar Castellanos
Nov 29, 2007·Cerebrovascular Diseases·Mar Castellanos, Joaquín Serena
Feb 28, 2008·Cerebrovascular Diseases·Soo Kyoung KimGyeong-Moon Kim
Feb 13, 2009·Expert Review of Neurotherapeutics·Adrià Arboix, Josep Lluís Martí-Vilalta
Aug 5, 2014·Journal of Translational Medicine·Patricia Martínez-SánchezExuperio Díez-Tejedor
Mar 16, 2011·Journal of the Neurological Sciences·Yasumasa YamamotoIchiro Akiguchi
Jul 27, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yong Bum KimPil-Wook Chung
Oct 20, 2009·Journal of the Neurological Sciences·Yasumasa YamamotoKotaro Ozasa
Jan 29, 2008·Journal of the Neurological Sciences·Yuka TerasawaRyuji Kaji
Apr 3, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Alessandra Del BeneDomenico Inzitari
Jan 6, 2007·Veterinary Ophthalmology·John H RossmeislIan P Herring
Mar 19, 2016·Revue neurologique·I MaestriniR Bordet
Feb 11, 2012·British Journal of Clinical Pharmacology·Nazeeha HasanPankaj Sharma
Oct 4, 2006·Experimental Neurology·Alexander ZlotnikVivian I Teichberg
Jun 11, 2009·Journal of Clinical Neurology·Heui-Soo MoonPil-Wook Chung
May 21, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Mariko TakeuchiKazuyuki Nagatsuka
Feb 23, 2018·Acta Neurologica Scandinavica·S Y HaK J Shin
Nov 24, 2004·Journal of Magnetic Resonance Imaging : JMRI·Kei YamadaTsunehiko Nishimura
Nov 4, 2016·International Journal of Stroke : Official Journal of the International Stroke Society·Tomohiro KawanoKazuyuki Nagatsuka
May 18, 2018·Acta Neurologica Scandinavica·V ManteroA Salmaggi
Sep 20, 2018·Acta Neurologica Scandinavica·Halvor NaessChristopher E Kvistad
Feb 14, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Salvatore RudilossoXabier Urra
Jan 30, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A BerberichP Ringleb
Jan 12, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Ki-Woong NamByung-Woo Yoon

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