PMID: 2504233May 1, 1989Paper

Neurological disorders in AIDS and HIV disease in the northern zone of Tanzania

AIDS
W P HowlettW R Missalek

Abstract

This study presents the main clinical findings on 200 AIDS patients at Kilimanjaro Christian Medical Centre in the northern zone of Tanzania, with detailed neurological findings on 135 out of 200 cases and 53 controls. Results show that 21 out of 200 (10.5%) had an obvious focal neurological disorder, including cranial nerve palsies, hemiparesis and paraparesis. Ninety-seven out of 135 (72%) had less obviously detectable neurological disorders, versus 36% of controls (P less than 0.005). Most frequent were AIDS dementia complex (54%), retinopathy (23%), areflexia (21%), pyramidal tract signs (19%) and tremor and incoordination (19%). Frontal lobe release signs (FLRS) were found in 103 out of 135 (76%) patients, versus 36% of controls (P less than 0.005). Advanced and terminal AIDS cases were more likely to have neurological disorders than early AIDS patients. A further study on 87 non-AIDS patients with acute unexplained neurological disorders showed 10 out of 87 to be HIV seropositive. Three case studies are presented. This study suggests that neurological disorders are among the main clinical features of AIDS and HIV disease in Africa.

Citations

Aug 3, 2007·Nature Clinical Practice. Neurology·Ned SacktorDavid B Clifford
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kevin R Robertson, Colin D Hall
Dec 1, 1993·Annals of Tropical Medicine and Parasitology·C AtzoriM Scaglia
Jun 28, 2014·BMC Public Health·Alain LekoubouAndre P Kengne
Jul 12, 2011·AIDS and Behavior·Adelina HolguinCharles Wood
Jun 1, 1995·Acta Neurologica Scandinavica·W P HowlettS Nilssen
Jun 1, 2011·African Journal of AIDS Research : AJAR·Erica BreuerJohn A Joska
May 21, 2009·Neuropsychology Review·Kevin RobertsonRobert Heaton
Dec 17, 2014·Tropical Medicine & International Health : TM & IH·Lena Morgon BanksHannah Kuper
Jul 6, 2017·Practical Neurology·Marieke C J DekkerWilliam P Howlett
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·E A O'Keefe, R Wood

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