Neurological heterotopic ossification: Current understanding and future directions

Bone
Rhys D BradyTerence J O'Brien

Abstract

Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. NHO often forms around the hip, knee and shoulder joints, causing severe pain and joint deformation which is associated with significant morbidity and reduced quality of life. The cellular and molecular events that initiate NHO have been the focus of an increasing number of human and animal studies over the past decade, with this work largely driven by the need to unearth potential therapeutic interventions to prevent the formation of NHO. This review provides an overview of the present understanding of NHO pathogenesis and pathobiology, current treatments, novel therapeutic targets, potential biomarkers and future directions.

Citations

Sep 5, 2020·Journal of Cellular and Molecular Medicine·Natália TőkésiAndrás Váradi
Jun 23, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hsu-Wen TsengKylie A Alexander
Mar 23, 2019·Frontiers in Immunology·Kylie A AlexanderJean-Pierre Levesque
Feb 12, 2020·Journal of Neurotrauma·Stuart J McDonaldFrances Corrigan
Jul 17, 2020·International Journal of Molecular Sciences·Ellen OttoJohannes Keller
Feb 4, 2021·Mediators of Inflammation·Katharina RitterMichael K E Schäfer
Mar 23, 2021·Frontiers in Cell and Developmental Biology·Dorothée GirardSébastien Banzet

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