Neurological impairment in rats after subarachnoid hemorrhage--a comparison of functional tests

Journal of the Neurological Sciences
Serge C ThalStefan Zausinger

Abstract

Functional outcome has become a key parameter for the determination of the efficacy of therapeutic interventions. Unfortunately, functional tests are not established for filament perforation induced subarachnoid hemorrhage (SAH). Therefore, we evaluated generally applied functional tasks for their potential to discriminate between various degrees of neuronal damage. Rats were subjected to SAH by an endovascular filament and were randomly assigned to controls treated with 0.9% NaCl, moderately neuroprotective therapy with 7.5% NaCl, and highly effective neuroprotection by 7.5% NaCl+6% dextran 70 (HSD). Functional deficit was quantified daily using beam balance task, prehensile traction task, rotarod, a 6-point motor function score and a general neurological 100-point score. Only the HSD group exhibited significantly more surviving neurons at postoperative day 7. Despite significant variations in histomorphometry, beam balance, prehensile traction and rotarod failed to distinguish between groups. On the other hand, the 100-point neuroscore showed improved neurological recovery on postoperative day 1 for HSD. The 100-point neuroscore failed to discriminate between treatment arms at later time points and therefore seems to reflect ...Continue Reading

References

Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·T X GionetJ R West
Sep 1, 1991·Journal of Pharmacological Methods·S M CartmellD Mitchell
Apr 1, 1990·Journal of Neurosurgery·J E BailesH Z Baldwin
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
May 1, 1989·Stroke; a Journal of Cerebral Circulation·L PerssonY Olsson
Mar 1, 1987·Stroke; a Journal of Cerebral Circulation·D J Combs, L G D'Alecy
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Dec 1, 1983·Neurosurgery·B LjunggrenL Brandt
Mar 1, 1984·Stroke; a Journal of Cerebral Circulation·G GéraudA Bes
Jan 28, 1982·Brain Research·E J Neafsey, C Sievert
Nov 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L KatzR Neumar
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M OkadaM Fujiwara
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D S WarnerE Weber
Jun 1, 1994·Journal of Neurotrauma·A F GermanòF Tomasello
Jul 1, 1994·Stroke; a Journal of Cerebral Circulation·J P BroderickA Leach
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T J DeGrabaJ C Grotta
Jun 1, 1993·Stroke; a Journal of Cerebral Circulation·M GrabowskiB B Johansson
Nov 1, 1995·Physiology & Behavior·C V BorlonganP R Sanberg
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M NagayamaC Iadecola
Aug 9, 2003·Intensive Care Medicine·Yalçin KocaoğullarDamirez Fossett
Sep 1, 2004·Neurosurgery·Stefan ZausingerRobert Schmid-Elsaesser
Oct 10, 2006·Artificial Organs·Johannes BoltzeFrank Emmrich

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Citations

Feb 17, 2009·Journal of Neurotrauma·Crystal L MacLellanFrederick Colbourne
Aug 27, 2009·BMC Neuroscience·Hyojin JeonR Loch Macdonald
Aug 25, 2010·Critical Care : the Official Journal of the Critical Care Forum·Pieter M CobelensWalter M van den Bergh
Mar 15, 2012·Progress in Neurobiology·Fatima A SehbaJohn H Zhang
Jun 21, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Paul R KrafftCathie L M Sudlow
Sep 30, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nefize TuranGustavo Pradilla
Apr 12, 2019·Journal of the American Heart Association·Kanako MatsumuraDevin W McBride
Feb 20, 2016·Experimental and Therapeutic Medicine·Ji-Yan LinXiao-Xing Liao
Nov 29, 2016·The Journal of Clinical Investigation·Roslyn A TaylorLauren H Sansing
Jul 1, 2017·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Mirla Fiuza DinizSavio Lana Siqueira

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