PMID: 11343941May 10, 2001Paper

Neurological injury after surgery for ischemic heart disease: risk factors, outcome and role of metabolic interventions

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
R SvedjeholmFarkas B Vánky

Abstract

Neurological complication remains a feared and increasing problem in association with cardiac surgery. The aim of this study was to analyze risk factors for neurological complications in a cohort of patients in whom inotropes for weaning from cardiopulmonary bypass was gradually replaced by metabolic treatment. The records of 775 consecutive patients undergoing coronary artery bypass grafting (CABG) or combined CABG+valve procedures were examined. Forward stepwise multiple logistic regression analysis was used for statistical evaluation of independent risk factors. The incidence of neurological injury was 1.8% in patients undergoing isolated CABG and 5.4% after combined CABG+valve procedures. After cross-validation multivariate analysis identified history of cerebrovascular disease, advanced age and aortic cross-clamp time as independent risk factors for postoperative cerebral complications. Chronic obstructive pulmonary disease and number of bypasses also emerged as risk factors in the primary analysis. In general, markers for advanced atherosclerosis, with history of cerebrovascular disease as the most important, emerged as predictors for neurological injury. Although it did not enter the final risk model, the results also su...Continue Reading

Associated Clinical Trials

Jun 21, 2007·Rolf SvedjeholmRolf Svedjeholm

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Citations

Sep 24, 2005·Journal of Medical Systems·Lisa RidderstolpeHans Ahlfeldt
Mar 31, 2007·Seminars in Thoracic and Cardiovascular Surgery·Jeremiah R BrownAnthony P Furnary
Dec 29, 2004·The Annals of Thoracic Surgery·Paulin AndréllChristian Blomstrand
Feb 10, 2010·Scandinavian Cardiovascular Journal : SCJ·Rolf SvedjeholmErik Håkanson
Jun 23, 2012·The Journal of Thoracic and Cardiovascular Surgery·Mårten VidlundRolf Svedjeholm
Nov 24, 2001·The Journal of Biological Chemistry·Qiaofang ChenGabriel G Haddad

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