Neurological manifestations of primary Sjögren's syndrome

Reumatologia
Joanna Perzyńska-MazanRobert Gasik

Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune connective tissue disease affecting the exocrine glands, leading to damage of their structure and impairment of their function. In the course of pSS the internal organs may be involved and the symptoms may concern any system. Neurological disorders are one of the most common extraglandular manifestations of pSS. Available literature data estimate the prevalence of neurological symptoms as about 8.5-70% of patients diagnosed with pSS. The most common neurological complication of pSS is peripheral neuropathy, and in particular sensory polyneuropathy. Central nervous system involvement is much less common. There are also reports of various symptoms connected with damage to cranial nerves and the autonomic nervous system. A careful neurological evaluation, combined with neurophysiological tests, is recommended in patients with pSS. This review summarizes the neurological manifestations of pSS, their possible pathogenic mechanisms, diagnostic evaluation and potential treatment.

Citations

Nov 28, 2019·Current Neurology and Neuroscience Reports·Regina M Troxell, Alison Christy
Feb 23, 2020·International Journal of Molecular Sciences·Michie ImamuraShunya Nakane
Apr 18, 2019·Brain Sciences·Ciro ManzoJordi Serra-Mestres
Jun 7, 2020·Clinical Rheumatology·Veli YazisizMustafa Ender Terzioğlu
Nov 26, 2020·The Journal of International Medical Research·Huijia YangDihui Ma
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Apr 15, 2021·Journal of Neuroimmunology·Chenchen LiuBitao Bu
May 1, 2021·Journal of Clinical Medicine·Meletios RozisDimitrios Stergios Evangelopoulos
Oct 7, 2021·Acta neurologica Belgica·Andreas LiampasPanagiotis Zis
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Oct 5, 2021·Rheumatology·José M Pego-Reigosa, Íñigo Rúa-Figueroa Fernández de Larrinoa

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BETA
biopsy

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