Neurological Predictors of Clinical Outcomes in Hospitalized Patients With COVID-19

Frontiers in Neurology
Hisham SalahuddinMouhammad A Jumaa

Abstract

Introduction: Multiple risk factors of mortality have been identified in patients with COVID-19. Here, we sought to determine the effect of a history of neurological disorder and development of neurological manifestations on mortality in hospitalized patients with COVID-19. Methods: From March 20 to May 20, 2020, hospitalized patients with laboratory confirmed or highly suspected COVID-19 were identified at four hospitals in Ohio. Previous history of neurological disease was classified by severity (major or minor). Neurological manifestations during disease course were also grouped into major and minor manifestations. Encephalopathy, ischemic or hemorrhagic stroke, and seizures were defined as major manifestations, whereas minor neurological manifestations included headache, anosmia, dysgeusia, dizziness or vertigo, and myalgias. Multivariate logistic regression models were used to determine significant predictors of mortality in patients with COVID-19 infection. Results: 574/626 hospitalized patients were eligible for inclusion. Mean age of the 574 patients included in the analysis was 62.8 (SD 17.6), with 298 (51.9%) women. Of the cohort, 240(41.8%) patients had a prior history of neurological disease (HND), of which 204 (35....Continue Reading

References

Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 29, 2020·The New England Journal of Medicine·Temet M McMichaelUNKNOWN Public Health–Seattle and King County, EvergreenHealth, and CDC COVID-19 Investigation Team
Apr 7, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Takeshi MoriguchiShinji Shimada
Apr 10, 2020·The European Respiratory Journal·Rong-Hui DuHuan-Zhong Shi
Apr 14, 2020·The Journal of Infection·Qing YeJianhua Mao
Apr 29, 2020·The New England Journal of Medicine·Thomas J OxleyJohanna T Fifi
May 15, 2020·Annals of Clinical and Translational Neurology·Sana SomaniShruti Agnihotri
May 18, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Koy Chong Ng Kee KwongArpan R Mehta
Jun 1, 2020·EBioMedicine·Qi ChengJianqun Gao
Jun 3, 2020·Neurology·Carlos Manuel Romero-SánchezTomás Segura
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Alexander E MerklerBabak B Navi
Jun 24, 2020·Frontiers in Neurology·Hisham SalahuddinMouhammad A Jumaa

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Citations

Dec 23, 2020·Neuroscience Letters·Alberto VogrigMauro Morassi
Jan 19, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Johann SellnerUNKNOWN EAN NeuroCOVID-19 Task Force
Mar 23, 2021·International Journal of Audiology·Ibrahim Almufarrij, Kevin J Munro
Apr 6, 2021·Epilepsy & Behavior Reports·Sihyeong ParkImran Ali
Jul 15, 2021·ACS Chemical Neuroscience·Vitalakumar DS J S Flora
Aug 25, 2021·Journal of Translational Medicine·Yuanyuan HeHong Zhang
Aug 26, 2021·International Journal of Audiology·Melanie LoughKevin J Munro

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Methods Mentioned

BETA
PCR

Software Mentioned

R
ALBACOVID
Excel
EZR

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