PMID: 9555970Apr 29, 1998Paper

Neurological recovery in diabetic rats following spinal cord injury

Journal of Neurotrauma
M TariqK Al Moutaery

Abstract

This study was designed to assess the effect of spinal cord injury on neurobehavioral, electrophysiological, structural, and biochemical changes in normal and diabetic rats. Experimental diabetes was induced in Sprague-Dawley male rats (weighing 250-280 g) with streptozotocin (50 mg/kg i.p.). Eight weeks after the treatment with streptozotocin the animals were anaesthetized with chloral hydrate and laminectomy was performed at T 7-8 level leaving the dura intact. A compression plate (2.2 x 5.0 mm) loaded with a weight of 35 g was placed on the exposed spinal cord for 5 min. Postoperative neurological function was assessed using inclined plane test, modified Tarlov score, and vocal and sensory score daily for 10 days. Electrophysiological changes were assessed using somatosensory and corticomotor evoked-potentials. The animals were sacrificed at different time intervals and injured site of the spinal cord was analyzed for changes in vitamin E and glutathione levels (as markers of oxidative stress). Pathological changes in spinal cord were also studied using light microscopy. The data on neurobehavioral study clearly indicated that the compression of spinal cord produced highly significant neurological deficit and poor recovery i...Continue Reading

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Citations

Aug 8, 2002·Journal of Neurotrauma·Jen Hill LucasBradford T Stokes
Sep 30, 2000·Journal of Neurosurgery·K Al MoutaeryM Tariq
Mar 13, 2009·Neurological Research·Zhenghua HongZhangfu Wang
Dec 14, 2007·Annals of the New York Academy of Sciences·Hari Shanker Sharma
Jan 22, 2008·Epilepsy & Behavior : E&B·Mohammad TariqSaleh Al Deeb
Dec 2, 2000·Journal of Neurotrauma·V ElangovanE Shohami
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H KamencicB H Juurlink
Oct 27, 2020·Frontiers in Neuroscience·Michael ShaughnessKimberly R Byrnes

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