Neurological symptom burden impacts survival prognosis in patients with newly diagnosed non-small cell lung cancer brain metastases.

Cancer
Ariane SteindlAnna Sophie Berghoff

Abstract

Brain metastases (BM) are a frequent complication of advanced cancer and are characterized by a variety of neurological symptoms. Although the presence of neurological symptoms is included in the response assessment in patients with primary brain tumors, to the authors' knowledge little is known regarding the prognostic impact of neurological symptoms in patients with BM. Patients with newly diagnosed BM from non-small cell lung cancer were identified from the Vienna Brain Metastasis Registry and were evaluated according to the incidence, distribution, and prognostic impact of neurological symptoms at the time of diagnosis of BM. A total of 1608 patients (57.3% male and 42.7% female; median age, 62 years) were available for further analyses. Neurological symptoms including focal deficits (985 patients; 61.3%), signs of increased intracranial pressure (483 patients; 30.0%), epileptic seizures (224 patients; 13.9%), and neuropsychological symptoms (233 patients; 14.5%) were documented in 1186 of the 1608 patients (73.8%). Patients with asymptomatic BM presented with a longer median overall survival after the diagnosis of BM compared with patients with symptomatic BM (11 months vs 7 months; P < .001). In multivariate analysis with...Continue Reading

References

Sep 1, 1993·Neurology·P A Forsyth, J B Posner
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Francesco PignattiUNKNOWN European Organization for Research and Treatment of Cancer Radiotherapy Cooperative Group
Feb 26, 2004·Lancet Neurology·Martin J B Taphoorn, Martin Klein
Feb 28, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Amarnath JenaJai Bhagwan Sharma
Dec 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul W SperdutoMinesh Mehta
Mar 30, 2012·The Lancet Oncology·Kim MargolinF Stephen Hodi
Aug 14, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Matthias PreusserDamien C Weber
Apr 26, 2013·International Journal of Molecular Sciences·Petra SchödelMartin Andreas Proescholdt
Jun 6, 2014·The Oncologist·Charles J VechtAlberto Duran-Pena
Nov 9, 2015·Journal of Neuro-oncology·Johan A F KoekkoekMartin J B Taphoorn
Dec 10, 2015·Journal of Intensive Care Medicine·Yoshua EsquenaziKiwon Lee
Sep 16, 2017·Neurocritical Care·Rhonda CadenaJonathan J Ratcliff
Aug 29, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thanyanan ReungwetwattanaJohan Vansteenkiste

❮ Previous
Next ❯

Citations

Feb 5, 2021·Journal of Clinical Medicine·Alberto Caballero-VázquezGuillermo Arturo Cañadas-De la Fuente
Apr 4, 2021·Cancers·Martin A ProescholdtKarl-Michael Schebesch
May 9, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Viviane Teixeira Loiola de AlencarVladmir C Cordeiro de Lima
Aug 30, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nicholas J ThomasCaroline E McCoach

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT03769103

Software Mentioned

Statistical Package for the Social Sciences ( SPSS )
molGPA
Lung

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.