Neurology issues in schizophrenia

Current Psychiatry Reports
Katharina HüfnerAlex Hofer

Abstract

Schizophrenia ranks among the leading causes of disability worldwide. The presence of neurological signs co-occurring with the psychiatric symptoms is indicative of an organic brain pathology. In the present article, we review the current literature on neurology issues in schizophrenia. Firstly, common neurological signs found in patients with schizophrenia (neurological soft signs and smell abnormalities) and their association with imaging findings are reviewed. Secondly, the significant association of schizophrenia with epilepsy and stroke is described as well as the absent association with other organic brain diseases such as multiple sclerosis. Thirdly, we discuss the potential role of NMDA receptor antibodies in schizophrenia. Fourthly, neurological side effects of antipsychotic drugs and their treatment are reviewed; and lastly, we discuss neurocognitive deficits in patients with schizophrenia and their treatment. The focus of the review remains on articles with relevance to the clinician.

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Citations

May 16, 2017·Case Reports in Neurological Medicine·Dong Y HanSiddharth Kapoor
Apr 21, 2016·Antibodies·Carolin HoffmannPilar Martinez-Martinez
Oct 31, 2018·Frontiers in Neuroscience·Minmin HuXu-Feng Huang
May 1, 2021·International Journal of Environmental Research and Public Health·Suin ParkHyunlye Kim

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