Neurolymphomatosis: A report of 2 cases representing opposite ends of the clinical spectrum

Muscle & Nerve
Rajat LahoriaJennifer A Tracy

Abstract

Neurolymphomatosis (NL) is a rare disorder characterized by invasion of cranial or peripheral nerves, nerve roots, or plexi, usually by aggressive subtypes of non-Hodgkin lymphoma (NHL). The most common clinical presentation is that of a painful polyneuropathy or polyradiculopathy, followed by cranial neuropathy and, less frequently, by painless polyneuropathy. Clinical and pathologic findings are reported for 2 NL cases. The following 2 patients with NL, with disparate clinical presentations, are presented: a patient with subacute onset, painful, multifocal, mixed axonal and demyelinating radiculoplexus neuropathy due to a large B-cell NHL, who required 2 targeted fascicular nerve biopsies to demonstrate NL; and a patient with a slowly progressive, length-dependent axonal polyneuropathy due to a low-grade B-cell lymphoproliferative disorder, as shown on a diagnostic sural nerve biopsy. The cases described illustrate the wide clinical spectrum of NL.

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Citations

Jun 12, 2016·Journal of Neurology·Hisanori KinoshitaRyosuke Takahashi
Mar 19, 2004·The Journal of Emergency Medicine·Moti KleinGabriel M Gurman
May 26, 2017·Muscle & Nerve·Alberto PrioriLuca Tagliabue
Feb 22, 2018·Journal of Clinical Neuromuscular Disease·Ahmad DaherKarin Woodman
Jul 17, 2018·Journal of Neuropathology and Experimental Neurology·Mathilde DuchesneLaurent Magy
Feb 7, 2019·Frontiers in Neurology·Wijdan RaiAmro Maher Stino
Dec 21, 2021·Journal of Neuropathology and Experimental Neurology·M Adelita VizcainoCaterina Giannini

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