Neuromarkers of the common angiotensinogen polymorphism in healthy older adults: A comprehensive assessment of white matter integrity and cognition

Behavioural Brain Research
Lauren E SalminenRobert H Paul

Abstract

The common angiotensinogen (AGT) M268T polymorphism (rs699; historically referred to as M235T) has been identified as a significant risk factor for cerebrovascular pathologies, yet it is unclear if healthy older adults carrying the threonine amino acid variant have a greater risk for white matter damage in specific fiber tracts. Further, the impact of the threonine variant on cognitive function remains unknown. The present study utilized multiple indices of diffusion tensor imaging (DTI) and neuropsychological assessment to examine the integrity of specific white matter tracts and cognition between individuals with homozygous genotypes of M268T (MetMet n=27, ThrThr n=27). Differences in subcortical hyperintensity (SH) volume were also examined between groups. Results indicated that the threonine variant was associated with significantly reduced integrity in the superior longitudinal fasciculus (SLF) and the cingulate gyrus segment of the cingulum bundle (cingulum CG) compared to those with the methionine variant, and poorer cognitive performance on tests of attention/processing speed and language. Despite these associations, integrity of these tracts did not significantly mediate relationships between cognition and genetic stat...Continue Reading

References

Oct 2, 1992·Cell·X JeunemaitreJ M Lalouel
Nov 1, 1992·Journal of Computer Assisted Tomography·J V HajnalG M Bydder
Dec 1, 1985·Neurology·B T Volpe, C K Petito
Jul 1, 1983·Archives of General Psychiatry·M F FolsteinJ E Helzer
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·H S KimO Smithies
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E ConturoB H Robinson
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C Pierpaoli, P J Basser
Sep 1, 1996·Journal of Hypertension·A G JohnsonJ MaCallum
Sep 12, 1998·Nature Medicine·Y KakinumaA Fukamizu
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·C RandolphT N Chase
Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·T E ConturoM E Raichle
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·D J WerringA J Thompson
Jul 4, 2001·Clinical Cornerstone·H Chui
Feb 12, 2002·The American Journal of Cardiology·Thomas Unger
Sep 21, 2002·Journal of the International Neuropsychological Society : JINS·Ronald A CohenNorman Gordon
Nov 6, 2002·Journal of the Neurological Sciences·Gustavo C Román
Dec 19, 2002·NMR in Biomedicine·Susumu Mori, Peter C M van Zijl
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·M J McKinleyS Y Chai
May 2, 2003·Current Hypertension Reports·Teri A ManolioW T Longstreth
Jul 10, 2003·Lancet Neurology·Gustavo C RománHelena C Chui
Oct 31, 2003·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hedvig SöderlundLenore J Launer
Feb 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stanley J ColcombeSteriani Elavsky
Mar 11, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Ralph M Reitan, Deborah Wolfson
Oct 9, 2004·Stroke; a Journal of Cerebral Circulation·Helena SchmidtCornelia van Duijn
Jun 3, 2005·Journal of Cardiopulmonary Rehabilitation·John GunstadRonald A Cohen
Jun 29, 2005·Annals of Neurology·David BrennerUNKNOWN GENIC Investigators
Jul 12, 2005·Cerebrovascular Diseases·Robert H PaulRonald A Cohen
Feb 14, 2006·Neurobiology of Aging·Angela L JeffersonRonald A Cohen
Apr 26, 2006·Cellular and Molecular Neurobiology·Juan M SaavedraJin Zhou
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Sep 14, 2006·Annual Review of Psychology·David P MacKinnonMatthew S Fritz
Jan 2, 2007·International Journal of Cardiology·Andreana P HaleyRonald A Cohen
Jan 16, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·M J E van RijnC M van Duijn
May 15, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yolande B SaabMatthew J Ingram
Jul 5, 2007·Journal of the American Geriatrics Society·Angela L JeffersonRonald A Cohen

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Citations

Jun 13, 2017·Pharmacotherapy·Kristen M WardVicki L Ellingrod
Jun 19, 2019·Brain Imaging and Behavior·Paola M Garcia-EganRobert H Paul
Jul 25, 2021·Molecular Biology Reports·Anna PierzchlińskaMonika Białecka

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