Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice

Biochemical and Biophysical Research Communications
Keiko NakaharaN Murakami

Abstract

Following our recent observations of inactivity and slowed movement in neuromedin U knockout (NMU KO) mice, we compared nociceptive reflexes and environmental adaptation in NMU KO and wild-type mice. Hot plate and formalin tests revealed that reflexes to heat and pain were significantly decreased in NMU KO mice. Conversely, intracerebroventricular injection of NMU into wild-type mice stimulated nociceptive reflexes in a dose-dependent manner. After NMU injection, increased c-Fos expression was observed in a wide range of locations in hypothalamus, brainstem, and spinal cord. NMU mRNA expression increased in the spinal cord, but not in the hypothalamus, 2 and 4 h after formalin injection. When their light-dark cycle was advanced or retarded by 5 h, NMU KO mice required a longer time to re-entrain into the new light-dark cycle than did wild-type mice. Wild-type mice displayed increased blood pressure after their environmental temperature was changed from 23 to 37 degrees C, whereas no such increase was observed in NMU KO mice. Blood corticosterone levels were significantly increased after 10 min of immobilization stress in wild-type mice, but not in NMU KO mice. These results suggest that endogenous NMU may be involved in reflexe...Continue Reading

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Citations

Jul 13, 2005·The Journal of Experimental Medicine·Maiko MoriyamaMasayasu Kojima
Oct 13, 2006·Molecular and Cellular Biology·Hongkui ZengGeorge A Gaitanaris
Aug 2, 2008·PLoS Genetics·Carolin KosiolAdam Siepel
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May 16, 2009·General and Comparative Endocrinology·K YayouM Sutoh
Aug 5, 2008·Biochemical and Biophysical Research Communications·Takumi SakamotoNoboru Murakami
Jun 13, 2009·British Journal of Pharmacology·J D MitchellA P Davenport
Aug 4, 2009·Fundamental & Clinical Pharmacology·S Budhiraja, A Chugh
Jul 17, 2010·Annals of the New York Academy of Sciences·Yoshiki NakashimaMasayasu Kojima
Feb 10, 2006·Biochemical and Biophysical Research Communications·Maiko MoriyamaMasayasu Kojima
Sep 30, 2018·Journal of Medical Genetics·Xiao ChangHakon Hakonarson
Dec 24, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Maiko MoriyamaMasayasu Kojima
Dec 6, 2012·Physiological Genomics·Rosemarie PanettaThierry Groblewski
Jan 21, 2012·The Journal of Pharmacology and Experimental Therapeutics·Ahmed A RahmanPaul M Pilowsky
Jan 22, 2015·Clinical Chemistry·Vanesa G Martinez, Lorraine O'Driscoll
Feb 6, 2020·Experimental and Therapeutic Medicine·Xiaojie RenWuhua Ma
Apr 17, 2009·The Journal of Pharmacology and Experimental Therapeutics·Jay J LiuJ Robert Bostwick
May 3, 2018·Scientific Reports·Alexander ChamessianThomas Van de Ven
Sep 6, 2020·Immunology·Yuan YeLuzheng Xue
Sep 19, 2019·Current Medicinal Chemistry·An De PrinsSteven Ballet

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