Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin

Annals of the New York Academy of Sciences
Yoshiki NakashimaMasayasu Kojima

Abstract

Neuromedin U (NMU) was originally isolated from porcine spinal cord and shown to be distributed in numerous tissues, including the gastrointestinal tract. However, little is known about the role of NMU in the regulation of gastrointestinal functions. We established a radioimmunoassay system that is exceptionally specific for mouse NMU and found high NMU content in the gastrointestinal tract, particularly in the Auerbach's and Meissner's plexi, suggesting a possible role of NMU in gastrointestinal motility. NMU promoted small intestinal transit, and NMU deficiency resulted in lowered intestinal motility rate and diminished the effect of serotonin-induced defecation and diarrhea. These results indicate that NMU promotes intestinal transit and maintains intestinal homeostasis.

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Citations

Apr 22, 2015·Peptides·Louise S DalbøgeJacob Jelsing
Jun 29, 2017·Journal of Medicinal Chemistry·Yoko Kanematsu-YamakiTaiji Asami
Feb 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anne-Charlotte JarryMaude Le Gall
Jan 22, 2015·Clinical Chemistry·Vanesa G Martinez, Lorraine O'Driscoll
Jul 28, 2016·PloS One·Yoshiko MizukawaTetsuo Shiohara
Jun 8, 2019·Molecular Medicine Reports·Lin GuoYun Wang
May 19, 2011·Endocrinology·Andrea M PeierDonald J Marsh
Oct 24, 2017·British Journal of Pharmacology·Hiroaki NagaiShiro Takekawa
Sep 3, 2017·Biochemical and Biophysical Research Communications·Weidong ZhangMasamitsu Nakazato
May 1, 2021·International Journal of Molecular Sciences·Hitoshi Teranishi, Reiko Hanada

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