Neuromelanin imaging and midbrain volumetry in progressive supranuclear palsy and Parkinson's disease

Movement Disorders : Official Journal of the Movement Disorder Society
Daisuke TaniguchiNobutaka Hattori

Abstract

Background Nigral degeneration patterns differ between PSP and PD. However, the relationship between nigral degeneration and midbrain atrophy in PSP remains unclear. Objective We analyzed differences and relationships between nigral degeneration and midbrain atrophy in PSP and PD. Methods Neuromelanin-sensitive MRI and midbrain volumetry were performed in 11 PSP patients, 24 PD patients, and 10 controls to measure the neuromelanin-sensitive SNpc area and midbrain volume. Results The neuromelanin-sensitive SNpc area and midbrain volume were significantly smaller in PSP patients compared with PD patients and controls. Motor deficits were inversely correlated with neuromelanin-sensitive SNpc area in PD, but not PSP patients. There was no significant correlation between neuromelanin-sensitive SNpc area and midbrain volume in either disease group. Midbrain volumetry discriminated PSP from PD. Diagnostic accuracy was improved when neuromelanin-sensitive MRI analysis was added. Conclusions Neuromelanin-sensitive MRI and midbrain volumetry may reflect the clinical and pathological characteristics of PSP and PD. Combining neuromelanin-sensitive MRI and midbrain volumetry may be useful for differentiating PSP from PD. © 2018 Internationa...Continue Reading

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Citations

Nov 12, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Nadya PyatigorskayaStéphane Lehericy
Aug 29, 2020·Brain : a Journal of Neurology·Emma BiondettiStéphane Lehéricy
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·David E Vaillancourt, Stéphane Lehericy
Jun 20, 2019·Current Neurology and Neuroscience Reports·Stéphane PrangeStéphane Thobois
May 29, 2019·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A OkuzumiN Hattori
Aug 9, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiangming WangLing Yang
Mar 14, 2021·Journal of the Neurological Sciences·Shinsuke FujiokaYoshi Tsuboi
Mar 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Rahul GauravStéphane Lehéricy
Apr 6, 2021·Movement Disorders Clinical Practice·Takashi OgawaNobutaka Hattori
May 20, 2021·Current Opinion in Neurology·Lydia ChougarStéphane Lehéricy

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