Neuromodulation of Attention

Neuron
Alexander Thiele, Mark A Bellgrove

Abstract

Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic and neuropsychiatric disorders. Although years of research indicates that distinct neuromodulators influence attentional control, a mechanistic account that traverses levels of analysis (cells, circuits, behavior) is missing. However, such an account is critical to guide the development of next-generation pharmacotherapies aimed at forestalling or remediating the global burden associated with disorders of attention. Here, we summarize current neuroscientific understanding of how attention affects single neurons and networks of neurons. We then review key results that have informed our understanding of how neuromodulation shapes these neuron and network properties and thereby enables the appropriate allocation of attention to relevant external or internal events. Finally, we highlight areas where we believe hypotheses can be formulated and tackled experimentally in the near future, thereby critically increasing our mechanistic understanding of how attention is implemented at the cellular and network levels.

Citations

Jan 10, 2019·Learning & Behavior·Julia Ruiz-OliveiraAna Carolina Luchiari
May 7, 2019·Glia·Ksenia V KastanenkaElena Galea
Sep 29, 2019·Journal of Cognitive Neuroscience·Veronica Mäki-MarttunenThomas Espeseth
Sep 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Miguel DasilvaAlexander Thiele
Apr 16, 2020·The European Journal of Neuroscience·Yiqing LuVictoria Booth
Dec 13, 2019·Nature Communications·Ilona M Bloem, Sam Ling
Apr 7, 2020·Annual Review of Neuroscience·David A McCormickBiyu J He
Dec 5, 2018·Proceedings of the National Academy of Sciences of the United States of America·Daniel ZaldivarJozien Goense
Dec 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Thomas Zhihao Luo, John H R Maunsell
Apr 11, 2019·ELife·Dmitry KobakAlfonso Renart
Nov 2, 2019·Cerebral Cortex·Jakub Limanowski, Karl Friston
Apr 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rodrigo Quian Quiroga
Apr 15, 2020·Proceedings of the National Academy of Sciences of the United States of America·Morten L KringelbachGustavo Deco
Jan 9, 2020·Nature Reviews. Neuroscience·Katie A Ferguson, Jessica A Cardin
Jul 3, 2020·Scientific Reports·Erik BöhmMarkus Rothermel
Aug 21, 2019·The European Journal of Neuroscience·Tobias A Wagner-AltendorfJochen Roeper
Jan 7, 2021·Neuron·Jochem van KempenAlexander Thiele
Aug 11, 2020·Neuroscience Letters·Alfonso MagliacanoLuigi Trojano
Dec 11, 2020·Journal of Neurochemistry·Amir DudaiMichael London
Feb 3, 2021·Physiological Reports·Théo MilleSandrine S Bertrand
Jan 29, 2021·Attention, Perception & Psychophysics·Sean R O'Bryan, Miranda Scolari
Feb 9, 2021·Frontiers in Human Neuroscience·John R Kershner
Feb 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jun WangHan Xu
Oct 23, 2020·Communications Biology·Bahareh TaghizadehJacqueline Gottlieb
Dec 15, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire O'CallaghanJames M Shine
Apr 26, 2020·Trends in Cognitive Sciences·Siddhartha Joshi, Joshua I Gold
Feb 19, 2021·PLoS Computational Biology·Carlos Coronel-OliverosPatricio Orio
Jul 17, 2020·Brain and Cognition·Samira AminihajibashiThomas Espeseth
Apr 2, 2021·Nature Communications·Supriya Ghosh, John H R Maunsell

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Methods Mentioned

BETA
pharmacotherapies
sedation

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