Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain.

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Xueshu TaoRu-Rong Ji

Abstract

The current crises in opioid abuse and chronic pain call for the development of nonopioid and nonpharmacological therapeutics for pain relief. Neuromodulation-based approaches, such as spinal cord stimulation, dorsal root ganglion simulation, and nerve stimulation including vagus nerve stimulation, have shown efficacy in achieving pain control in preclinical and clinical studies. However, the mechanisms by which neuromodulation alleviates pain are not fully understood. Accumulating evidence suggests that neuromodulation regulates inflammation and neuroinflammation-a localized inflammation in peripheral nerves, dorsal root ganglia/trigeminal ganglia, and spinal cord/brain-through neuro-immune interactions. Specialized proresolving mediators (SPMs) such as resolvins, protectins, maresins, and lipoxins are lipid molecules produced during the resolution phase of inflammation and exhibit multiple beneficial effects in resolving inflammation in various animal models. Recent studies suggest that SPMs inhibit inflammatory pain, postoperative pain, neuropathic pain, and cancer pain in rodent models via immune, glial, and neuronal modulations. It is noteworthy that sham surgery is sufficient to elevate resolvin levels and may serve as a ...Continue Reading

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Citations

Aug 21, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christopher R DonnellyRu-Rong Ji
Mar 10, 2021·Organic & Biomolecular Chemistry·Jannicke Irina NesmanTrond Vidar Hansen
Apr 5, 2021·The Journal of Pain : Official Journal of the American Pain Society·Megan L FalsettaDavid C Foster
May 26, 2021·BMC Oral Health·Davy AubeuxAlexis Gaudin
Oct 16, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Christine N Sang, William K Schmidt
Jul 9, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pauline BottemanneGiulio G Muccioli

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xenograft
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