Neuromodulation Strategies in Post-Traumatic Stress Disorder: From Preclinical Models to Clinical Applications

Brain Sciences
Flavia V GouveiaClement Hamani

Abstract

Post-traumatic stress disorder (PTSD) is an often debilitating disease with a lifetime prevalence rate between 5⁻8%. In war veterans, these numbers are even higher, reaching approximately 10% to 25%. Although most patients benefit from the use of medications and psychotherapy, approximately 20% to 30% do not have an adequate response to conventional treatments. Neuromodulation strategies have been investigated for various psychiatric disorders with promising results, and may represent an important treatment option for individuals with difficult-to-treat forms of PTSD. We review the relevant neurocircuitry and preclinical stimulation studies in models of fear and anxiety, as well as clinical data on the use of transcranial direct current stimulation (tDCS), repetitive transcranial magnetic stimulation (rTMS), and deep brain stimulation (DBS) for the treatment of PTSD.

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Citations

Sep 17, 2020·Expert Review of Medical Devices·Beata Jarosiewicz, Martha Morrell
Jul 25, 2019·Brain Sciences·Joseph K CarpenterStefan G Hofmann
May 30, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Flavia Venetucci GouveiaClement Hamani
Sep 9, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jun OmuraShigeru Morinobu

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