Neuromodulators, stress and plasticity: a role for endocannabinoid signalling

The Journal of Experimental Biology
Laura Senst, Jaideep S Bains

Abstract

Any unanticipated threat to survival triggers an immediate sequence of events in the brain that culminate in a coordinated neural, endocrine and behavioural response. There is increasing evidence that stress itself modifies neural circuits. In other words, neural stress circuits learn from stress. This self-teaching is surprising as one might expect these essential circuits to be hard-wired. Our recent findings, however, indicate that repeated homotypic stress in rats causes functional changes in neural circuitry in the hypothalamus. In particular, we focus on signalling via endocannabinoids and describe plasticity in this system that impacts fast retrograde signalling at synapses on to the stress command neurons in the brain. Interestingly, this plasticity appears to be limited to early adolescence, hinting at unique modes of control of neural circuits by stress during different developmental stages.

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Citations

Aug 30, 2014·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Masanobu Kano
Jun 13, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria MorenaMatthew N Hill
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Jul 24, 2018·Frontiers in Behavioral Neuroscience·Lívea Dornela GodoyEduardo Henrique de Lima Umeoka
Dec 20, 2013·The Journal of Experimental Biology·Pat Monaghan
Aug 4, 2021·Neuropharmacology·Bryony Laura Winters, Christopher Walter Vaughan

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