Neuromodulatory control of localized dendritic spiking in critical period cortex

Nature
Courtney E YaegerJoshua T Trachtenberg

Abstract

Sensory experience in early postnatal life, during so-called critical periods, restructures neural circuitry to enhance information processing1. Why the cortex is susceptible to sensory instruction in early life and why this susceptibility wanes with age are unclear. Here we define a developmentally restricted engagement of inhibitory circuitry that shapes localized dendritic activity and is needed for vision to drive the emergence of binocular visual responses in the mouse primary visual cortex. We find that at the peak of the critical period for binocular plasticity, acetylcholine released from the basal forebrain during periods of heightened arousal directly excites somatostatin (SST)-expressing interneurons. Their inhibition of pyramidal cell dendrites and of fast-spiking, parvalbumin-expressing interneurons enhances branch-specific dendritic responses and somatic spike rates within pyramidal cells. By adulthood, this cholinergic sensitivity is lost, and compartmentalized dendritic responses are absent but can be re-instated by optogenetic activation of SST cells. Conversely, suppressing SST cell activity during the critical period prevents the normal development of binocular receptive fields by impairing the maturation of ...Continue Reading

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Citations

Nov 9, 2019·Nature Communications·Katharina Anna Wilmes, Claudia Clopath
Oct 1, 2019·Neural Plasticity·Adema Ribic, Thomas Biederer
Jun 6, 2020·Frontiers in Neural Circuits·Daniel A CantuCarlos Portera-Cailliau
Dec 18, 2019·Nature Neuroscience·Kirstie A Cummings, Roger L Clem
Nov 25, 2020·Current Protocols in Neuroscience·Daniel J LiputSteven S Vogel
Sep 14, 2019·Behavioural Brain Research·Ewa Siucinska
Nov 3, 2020·Frontiers in Cellular Neuroscience·Nathalie Dehorter, Isabel Del Pino
Nov 14, 2020·Nature Reviews. Neuroscience·Mary T Joy, S Thomas Carmichael
May 27, 2021·Seminars in Cell & Developmental Biology·Anne Teissier, Alessandra Pierani
Jul 20, 2021·Neuroscience·George StuytLucy M Palmer

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Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.