Neuromodulatory role of serotonin in the ferret thalamus

Journal of Neurophysiology
James E Monckton, David A McCormick

Abstract

Serotonergic fibers broadly innervate the thalamus and may influence the sleep wake cycle, attention, and other processes through modulation of neurons in this structure. However, the actions of serotonin in the dorsal thalamus have been investigated in detail only in the dorsal lateral geniculate nucleus. In the present study, we examined the action of serotonin in several different regions of the ferret dorsal thalamus, including the associative nuclei, using the in vitro slice preparation and intracellular recording techniques. In nearly all nuclei examined, the predominant action of serotonin was one of hyperpolarization and inhibition of the tonic firing mode. The magnitude of the hyperpolarizing response decreased with age and varied greatly across and somewhat within nuclei maintaining the following relationship (in descending order of magnitude): lateral posterior, lateral dorsal, pulvinar, mediodorsal, center median, anteroventral, central lateral, ventral basal, and medial geniculate. This hyperpolarization is elicited through two mechanisms: one direct and the other via local interneurons. The direct action occurs through an increase in potassium conductance mediated through the 5-HT(1A) receptor. This conclusion is ...Continue Reading

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Citations

Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gordon F Buchanan, George B Richerson
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tohei YokogawaHarold A Burgess
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