Neuromuscular block and current treatment strategies for its reversal in children

Paediatric Anaesthesia
Olli A Meretoja

Abstract

Even though neuromuscular blocking agents are an essential part of balanced anesthesia and the risks of residual paralysis are well documented, many anesthetists seldomly monitor neuromuscular block. Classical reversal agent neostigmine is unable to antagonise a deep neuromuscular block and is rather slow to antagonise even a moderate block. These caveats may have introduced a practice to use muscle relaxants mainly for an endotracheal intubation. This review presents current views on the effects of muscle relaxants and their reversal agents in pediatric patients. This may help clinicians to reconsider the value of muscle relaxants during anesthesia in children.

Associated Clinical Trials

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Citations

May 15, 2012·Pediatric Surgery International·Mostafa SomriIbrahim Matter
Jun 13, 2015·Anesthesiology Research and Practice·Thomas LedowskiBritta S von Ungern-Sternberg
Dec 2, 2014·Revista brasileira de anestesiologia·Turhan KaraSibel Oba
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Nov 27, 2019·Paediatric Anaesthesia·Francis Veyckemans
Nov 10, 2016·European Journal of Anaesthesiology·Ricardo V CarlosMaria José Carvalho Carmona
Mar 2, 2018·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·N'Diris BarryJoseph D Tobias
Apr 23, 2020·Saudi Journal of Anaesthesia·Sujana DontukurthyJoseph D Tobias
Jun 6, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Abdulraouf LamoshiDavid H Rothstein
Nov 20, 2016·Paediatric Anaesthesia·Joseph D Tobias
Oct 19, 2017·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Adele KingJoseph D Tobias
Feb 9, 2016·The Journal of Critical Care Medicine·Tiberiu EzriYitzhak Berlovitz
Sep 19, 2019·Acta Anaesthesiologica Scandinavica·Flora T ScheffenbichlerMatthias Eikermann
Mar 8, 2021·Journal of Pain and Symptom Management·Rafael LemusJoseph D Tobias

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