PMID: 27936Jan 1, 1978Paper

Neuromuscular blockade of fazadinium bromide (AH 8165) in renal failure patients

Acta Anaesthesiologica Scandinavica
F Camu, A A D'Hollander

Abstract

Fazadinium bromide (AH 8165) is a new non-depolarizing neuromuscular blocking agent with rapid onset of action and intermediate duration of effect. The characteristics of the neuromuscular blockade induced were compared in normal and renal failure patients by monitoring the mechanical responses of thumb adductor muscle to ulnar nerve stimulation. The data suggest that renal failure, even in anephric patients, does not influence the depth of neuromuscular relaxation when judged from the identical dose-effect curves in both groups of patients. Moreover, the duration of the neuromuscular block was not significantly increased in end-stage kidney failure patients, whether the initial or late phases of the spontaneous recovery of neuromuscular transmission were considered, and this occurred over the entire therapeutic range. However, additional incremental injections of fazadinium bromide should be used cautiously, as evidence appeared of prolonged duration of action. This agent, fazadinium bromide, may therefore present useful advantages to other non-depolarizing neuromuscular blocking agents as to clinical safety and effects in patients with renal insufficiency.

References

Mar 1, 1976·British Journal of Anaesthesia·R D Miller, D J Cullen
Apr 1, 1976·British Journal of Anaesthesia·K McLeodM D Rawlins
Aug 1, 1973·The Journal of Pharmacy and Pharmacology·B SrinivasanB Pleuvry
Nov 1, 1972·Canadian Anaesthetists' Society Journal·J S AnandD H Mulla
Feb 1, 1972·British Journal of Anaesthesia·M GibaldiW L Hayton
Oct 1, 1966·British Journal of Anaesthesia·L Strunin
Jun 1, 1969·Anesthesiology·S A FeldmanR C Golling
Mar 1, 1967·Anesthesiology·E N CohenD Smith

Citations

Dec 1, 1981·The Australian and New Zealand Journal of Surgery·J Gomez-ArnauF Avello
Nov 1, 1983·Anaesthesia and Intensive Care·P J Maddern
Sep 1, 1980·Anaesthesia·D R BevanR L Smith
Jan 1, 1983·European Journal of Clinical Pharmacology·A A d'HollanderJ M Desmonts
Jan 1, 1981·European Journal of Clinical Pharmacology·D R BevanR L Smith

Related Concepts

Dose-Response Relationship, Drug
Drug Evaluation
Kidney Failure, Chronic
Neuromuscular Blocking Agents
Pyridinium Compounds

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