Neuromuscular blocking action of two brevetoxins from the Florida red tide organism Ptychodiscus brevis

Toxicon : Official Journal of the International Society on Toxinology
D G BadenI Leung

Abstract

The action of Ptychodiscus brevis "brevetoxins" T17 and T34 on rat phrenic nerve-stimulated hemidiaphragm contraction is reported. The potency of T34 is greater than the potency of T17, but both cause a complete block of neuromuscular transmission in the nM to pM concentration ranges. Preparations exposed to low concentrations of T17 can recover in the presence of the toxin, whereas the effects of T34 are irreversible. The initial contracture produced by each is prevented by tetrodotoxin or curare. Neuromuscular block does not appear to be due to acetylcholine depletion, as determined by electron microscope examination of the neuromuscular junctions of blocked preparations. Persistent nerve depolarization is believed to be responsible for the neuromuscular block.

References

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Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·D G BadenI Leung
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Citations

Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·R H Pierce
Jan 1, 1989·Toxicon : Official Journal of the International Society on Toxinology·D R Franz, R D LeClaire
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·I S RichardsR Pierce
Jan 1, 1991·Toxicon : Official Journal of the International Society on Toxinology·V L Trainer, D G Baden
Apr 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·S S DeshpandeR E Sheridan
Aug 1, 1993·Toxicon : Official Journal of the International Society on Toxinology·R J LewisM Sellin
Jan 1, 1993·Brain Research Bulletin·J P AplandR E Sheridan
Nov 15, 2013·Toxins·Rex Munday, John Reeve
Sep 19, 2009·Toxicon : Official Journal of the International Society on Toxinology·John A KalaitzisBrett A Neilan
Jan 15, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ira S Richards, Marie Bourgeois
Dec 1, 1986·British Journal of Pharmacology·W D AtchisonS M Vogel
Apr 13, 2002·The Journal of Organic Chemistry·Frank E McDonaldKenneth I Hardcastle

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