Neuromuscular complications associated with liver transplantation

Muscle & Nerve
E F WijdicksR A Krom

Abstract

We studied neuromuscular complications in a cohort of 520 patients with liver transplantation. Perioperative mononeuropathy developed in 9 patients. The peroneal nerve, radial nerve, and cutaneous branch of the femoral nerve were affected in 2 patients each. Two patients had herpes zoster-associated radiculopathy, and 1 patient had Horner's syndrome. Recovery was good in most patients. In 7 patients, severe quadriplegia complicated the perioperative course. In 5 patients, electrophysiologic studies suggested acute necrotic myopathy, and muscle biopsy specimens showed evidence of rhabdomyolysis in 1 patient. Outcome in survivors was good, all recovering completely. We conclude that neuromuscular complications in liver transplantation are uncommon (less than 1%) and do not significantly contribute to morbidity. Mononeuropathies may have iatrogenic perioperative causes, and rhabdomyolysis may be an important cause of generalized muscle weakness after liver transplantation.

References

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Citations

Jun 14, 2003·The Neurologist·Misha Pless, Sasha A Zivkovic
Oct 5, 2002·Transplantation·Saïda Rezaiguia-DelclauxFrançois Stéphan
Jul 19, 2011·Journal of Intensive Care Medicine·Aliaksei PustavoitauRobert Stevens
Jun 17, 1998·Muscle & Nerve·J V CampelloneD J Kramer
Jan 25, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael G DulitzAlan J Koffron
Mar 6, 2010·Metabolic Brain Disease·Francesca CampagnaP Amodio
Jan 20, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M GuarinoUNKNOWN EFNS
Aug 26, 2006·Critical Care Medicine·Bobby Varkey Maramattom, Eelco F M Wijdicks
May 27, 2015·Current Neurology and Neuroscience Reports·J David Avila, Saša Živković
Aug 1, 1996·Anesthesia and Analgesia·E F Wijdicks
Jul 1, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·W T Merritt
Sep 12, 2013·World Journal of Hepatology·Saša A Zivković

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