Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson's disease

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Marlieke ScholtenDaniel Weiss

Abstract

The pathophysiology of deep brain stimulation mechanisms and resistant freezing phenomena in idiopathic Parkinson's disease (iPD) remains incompletely understood. Further studies on the neuromuscular substrates are needed. We analyzed 16 patients with advanced iPD and bilateral subthalamic nucleus stimulation, and 13 age- and gender-matched healthy controls. Patients were tested after overnight withdrawal of medication with 'stimulation off' (StimOff) and 'stimulation on' (StimOn). Subjects performed continuous tapping of the right index finger with simultaneous recordings of biomechanical registration, EMG of finger flexors and extensors, and EEG. First, we analyzed EEG and EMG spectral measures comparing StimOff with healthy controls and StimOff with StimOn (irrespective of freezing). Second, we contrasted 'regular (unimpaired) tapping' and 'freezing' resistant to subthalamic neurostimulation as obtained in StimOn. iPD showed increased intermuscular coherence around 8Hz in StimOff that was reduced in StimOn. This 8Hz muscular activity was not coherent to cortical activity. 'Freezing' episodes showed increased muscle activity of finger flexors and extensors at 6-9Hz, and increased cortical activity at 7-11Hz. During transition...Continue Reading

References

Jan 1, 1989·Progress in Biophysics and Molecular Biology·J R RosenbergD M Halliday
Jan 1, 1993·Annals of Neurology·P J DelwaideA Maertens de Noordhout
Feb 22, 1997·Lancet·P Brown
May 7, 1999·Journal of Geriatric Psychiatry and Neurology·R CamicioliJ G Nutt
Dec 22, 1999·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T Mima, M Hallett
Jan 6, 2000·Progress in Neurobiology·P Brown
Apr 25, 2000·Brain : a Journal of Neurology·S MeunierM Vidailhet
May 19, 2000·Parkinsonism & Related Disorders·N GiladiA D Korczyn
May 18, 2001·Experimental Brain Research·B R BloemJ G van Dijk
Mar 2, 2002·Brain : a Journal of Neurology·Stephan SaleniusPeter Brown
Dec 13, 2002·Brain : a Journal of Neurology·Lars TimmermannAlfons Schnitzler
Nov 14, 2003·The New England Journal of Medicine·Paul KrackPierre Pollak
Mar 19, 2005·Brain : a Journal of Neurology·Paul SilbersteinPeter Brown
Sep 24, 2005·The European Journal of Neuroscience·Galit YogevJeffrey M Hausdorff
Jun 20, 2006·Journal of the Neurological Sciences·Nir Giladi, Jeffrey M Hausdorff
Jun 30, 2006·Journal of the Neurological Sciences·Bastiaan R BloemMarten Munneke
Aug 5, 2006·Brain Research Reviews·Wolfgang KlimeschSimon Hanslmayr
Sep 1, 2006·The New England Journal of Medicine·Günther DeuschlUNKNOWN German Parkinson Study Group, Neurostimulation Section
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Jul 22, 2008·Behavioural Neurology·S RahmanM Jahanshahi
Sep 2, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Monika Pötter-NergerJens Volkmann
Mar 25, 2009·The European Journal of Neuroscience·Alice NieuwboerStephan Swinnen
Jun 15, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Arnaud DelvalBastiaan R Bloem
Jul 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Joke SpildoorenAlice Nieuwboer
Jan 22, 2011·Computational Intelligence and Neuroscience·Robert OostenveldJan-Mathijs Schoffelen
Jul 23, 2011·Lancet Neurology·John G NuttAlice Nieuwboer
Nov 15, 2011·Brain : a Journal of Neurology·Sylvie RaoulRose Katz
Nov 15, 2011·Neuron·Thomas M JessellJohn S Kelly
Jan 11, 2012·Brain : a Journal of Neurology·Wesley ThevathasanPeter Brown
Feb 1, 2012·Neurorehabilitation and Neural Repair·Sarah VercruysseAlice Nieuwboer
Oct 17, 2012·JAMA Neurology·Scott E CooperJerrold L Vitek
Feb 15, 2013·The New England Journal of Medicine·W M M SchuepbachUNKNOWN EARLYSTIM Study Group
Jul 5, 2013·Brain : a Journal of Neurology·Brett W FlingFay B Horak
Oct 9, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·J M ShineS J G Lewis
Oct 11, 2013·Frontiers in Systems Neuroscience·James M ShineSimon J G Lewis

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Citations

May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·James M Shine
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marlieke ScholtenDaniel Weiss
Feb 18, 2020·Journal of Parkinson's Disease·Lívia ShirahigeKátia Monte-Silva
Oct 28, 2019·Brain : a Journal of Neurology·Daniel WeissSimon J G Lewis
Nov 27, 2020·Frontiers in Neurology·J Sebastian MarquezOu Bai

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