Neuromuscular frequency-coding and fatigue

Advances in Experimental Medicine and Biology
D Kernell

Abstract

In daily life, muscle fatigue often becomes noticeable as an apparent decline in the efficiency of force production by central commands, making it necessary to increase drive (or "effort") to produce a constant motor output. Such aspects of fatigue may be caused by changes in the way in which synaptic messages arriving at the motoneurons are translated into forces by the muscle fibers. Therefore, an understanding of these neuromuscular gradation mechanisms is essential for any analysis of motor fatigue. A brief general review is given of 1) how muscle fibers transduce motoneuronal discharge rates into force; 2) how synaptic currents are transduced into motoneuronal discharge rates; 3) how activity-dependent changes in the neuromuscular transduction mechanisms contribute to neuromuscular fatigue; and 4) how the matching between the transduction mechanisms of motoneurons and those of their muscle fibers may help to optimize neuromuscular gradation efficiency and decrease the severity of fatigue.

Citations

May 30, 1998·Journal of Neurophysiology·S A Binder-MacleodL J Kucharski
Nov 18, 2008·Muscle & Nerve·Chris M GregoryWarren E Dixon
Aug 14, 2012·Scandinavian Journal of Medicine & Science in Sports·N HedayatpourD Falla
Nov 2, 2002·The Journal of Comparative Neurology·Jennifer C McDonaghDouglas G Stuart
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Jun 4, 2021·European Journal of Applied Physiology·Benjamin KozlowskiGeoffrey A Power

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